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Alan Rose

Associate Project Scientist
Molecular and Cellular Biology (College of Biological Sciences)

126 Briggs Hall
Office (530)754-9892
Lab (530)752-3194
abrose@ucdavis.edu

[Picture of Alan Rose]

Degrees:
0 - BS - University of Waterloo - Biology
0 - MS - York University - Molecular Biology
0 - PhD - Princeton University - Molecular Biology

Department and Center Affiliations:
Molecular and Cellular Biology

Grad Group Affiliations and Specialties:
Biochemistry and Molecular Biology
Genetics
Plant Biology

Publications:
Rose, A.B., T. Elfersi, G. Parra, and I. Korf (2008) Promoter-Proximal Introns in Arabidopsis thaliana are Enriched in Dispersed Signals that Elevate Gene Expression. Plant Cell 20:543-551.

Rose, A.B. (2008). Intron-mediated regulation of gene expression. In Nuclear pre-mRNA Processing in Plants (A.S.N. Reddy and M. Golovkin, eds.) Springer-Verlag, New York. In press.

Rose, A.B. (2007) Book Review: Plant Gene Expression. Science STKE, pe26.

Belostotsky, D.A. and A.B. Rose (2005). Plant gene expression in the age of systems biology: Integrating transcriptional and post-transcriptional events. Trends in Plant Science 10:347-353.

Rose, A.B. (2004). The effect of intron location on intron-mediated enhancement of gene expression in Arabidopsis. Plant Journal 40:744-751.

Rose, A.B. (2002). Requirements for intron-mediated enhancement of gene expression in Arabidopsis. RNA. 8:1444-1453.

Shibagaki, N., A. Rose, J.P. McDermott, T. Fujiwara, H. Hayashi, T. Yoneyama, and J.P. Davies (2002). Selenate-resistant mutants of Arabidopsis thaliana identify Sultr1;2, a sulfate transporter required for efficient transport of sulfate into roots. Plant Journal 22:475-486.

Rose, A.B. and J.A. Beliakoff (2000). Intron-mediated enhancement of gene expression independent of unique intron sequences and splicing. Plant Physiology, 122:535-542.

Rose, A.B. and R.L. Last (1997). Introns act post-transcriptionally to increase expression of the Arabidopsis thaliana tryptophan pathway gene PAT1. Plant Journal 11:455-464.

Rose, A.B., J. Li, and R.L. Last (1997). An Allelic Series of Blue Fluorescent trp1 Mutants of Arabidopsis thaliana. Genetics 145:197-205.

Li, J., J. Zhao, A.B. Rose, R. Schmidt, and R.L. Last (1995). Arabidopsis phosphoribosylanthranilate isomerase: Molecular genetic analysis of triplicate tryptophan pathway genes. Plant Cell 7:447-461.

Rose, A.B., A.L. Casselman, and R.L. Last (1992). A phosphoribosylanthranilate transferase gene is defective in blue fluorescent Arabidopsis thaliana tryptophan mutants. Plant Physiology 100:582-592.

Research Interests:
Introns significantly increase the expression of many genes in plants and other organisms. I am interested in understanding the mechanistic basis for the effect of introns on gene expression in Arabidopsis. My main approach is to determine the requirements (intron sequences, structures, need for splicing, or position in a gene) for enhancement, and where possible to define biochemically the effect that introns have on the various stages of gene expression. I am collaborating with Ian Korf in the Genome Center in a computational analysis of introns, with the goals of identifying the intron sequences responsible for boosting expression and predicting the enhancing ability of introns.

Courses Taught:
PBI 298 Plant Molecular Biology Discussion
MCB 120L Biochemistry lab
BIS 102 Structure and Function of Macromolecules