Faculty Profile

Lesilee S. Rose
Professor of Molecular and Cellular Biology
Molecular and Cellular Biology (College of Biological Sciences)
3224 Life Sciences Addition
Office 754-9884/754-9891
Lab
lsrose@ucdavis.edu
[Picture of Lesilee S. Rose]

Degrees:
1991 - PhD - Princeton University - Molecular Biology
1986 - BS - College of William and Mary - Biology

Awards:
Basil O’Connor Starter Scholar Research Award

Department and Center Affiliations:
Section of Molecular and Cellular Biology

Professional Societies:
Society for Developmental Biology
Genetics Society of America
American Society for Cell Biology

Grad Group Affiliations and Specialties:
Biochemistry and Molecular Biology
Cell and Developmental Biology
Genetics

Publications:
DeBella, Leah R., Adam Hayashi, and Lesilee S. Rose. 2006. LET-711, the C. elegans NOT1 ortholog, is required for spindle positioning and regulation of microtubule length in embryos. Mol. Biol. Cell 17:4911-4924

Wu, Jui-Ching, and Lesilee S. Rose. 2007. PAR-3 and PAR-1 inhibit LET-99 localization to generate a cortical band important for spindle positioning in C. elegans embryos. 2007. Mol Biol Cell. 18:4470-82

Park, Dae Hwi and Lesilee S. Rose. Dynamic localization of LIN-5 and GPR-1/2 to cortical force generation domains during spindle positioning. Devel. Biol. In press

Goönczy, Pierre, and Lesilee S. Rose. 2005. Asymmetric cell division and axis formation in the embryo. In WormBook, ed.The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.7.1, http://www.wormbook.org.

Meng-Fu Bryan Tsou, Wei Ku, Adam Hayashi, and Lesilee S. Rose. 2003. PAR-dependent and geometry-dependent mechanisms of spindle positioning. J Cell Bio1: 160(6):845-55.

Meng-Fu Bryan Tsou, Adam Hayashi, and Lesilee S. Rose. 2003. LET-99 opposes Ga/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling. Development 130: 5717-30.

Tsou M-F, A Hayashi, LR. DeBella, G McGrath, and LS Rose. 2002. LET-99 determines spindle position and is asymmetrically enriched in response to PAR polarity cues in C. elegans embryos. Development. 129(19):4469-4481

Basham, SE and LS Rose. 2001. The Caenorhabditis elegans polarity gene ooc-5 encodes a Torsin-related protein of the AAA ATPase superfamily. Development. 128(22):4645-4656

Research Interests:
Developmental and cell biology of C. elegans, with an emphasis on the control of cell division patterns and polarity.

Laboratory Personnel:
Life Sciences Addition 3235/39 - Adam Hayashi, Lab Manager; Jui-Ching Wu, Graduate Student; Dae Hwi Park, Graduate Student; Lori Krueger, Graduate Student; Wei Li, Graduate Student;

Teaching Interests:


Developmental biology. Genetics.