Faculty Profile
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Maria Mudryj
Associate Professor of Microbiology and Immunology Microbiology and Immunology (School of Medicine) 3147 Tupper Hall Office 754-6090 Lab 754-6183 mmudryj@ucdavis.edu |
Degrees:
1987 - PhD - George Washington University - Genetics
1977 - BS - Johns Hopkins University - Biology
Department and Center Affiliations:
Medical Microbiology and Immunology
Cancer Center
Professional Societies:
American Association for Cancer Research
Grad Group Affiliations and Specialties:
Biochemistry and Molecular Biology
Genetics
Publications:
Honglin Devlin, Phillip C. Mack, Rebekah A. Burich, Paul H. Gumerlock, Hsing-Jien Kung, Maria Mudryj and Ralph W. deVere White. Impairment of the DNA Repair and Growth Arrest Pathways by p53R2 Silencing Enhances DNA Damage-Induced Apoptosis in a p53 Dependent Manner in Prostate Cancer (CaP) Cells. Molecular Cancer Research (in press).
Stephen Libertini, Clifford G. Tepper, Veronica Rodriguez, David M. Asmuth, Hsing-Jien Kung and Maria Mudryj. (2007) Evidence for Calpain mediated Androgen Receptor Cleavage as a Mechanism of Androgen Independence and Potential Therapeutic Target in Prostate Tumors. Cancer Research 69, 9001-5.
Maria Mudryj, Elizabeth Reay, Satya Dandekar, Laurel Beckett, Ralph DeVere White and Regina Gandour-Edwards. (2007) A novel p53/p130 axis in bladder tumors. Urology 70, 608-12.
Stephen Libertini, Clifford G. Tepper, Moraima Guadalupe, Ying Lu, David M. Asmuth and Maria Mudryj. (2006) E2F1 expression in LNCaP prostate cancer cells deregulates androgen dependent growth, suppresses differentiation, and enhances apoptosis. Prostate 66, 70-81.
Stephen J. Libertini, Brian Robinson, Navdeep K. Dhillon, Danielle Glick, Michael George, Satya Dandekar, Jeffrey P. Gregg, Earl Sawai, and Maria Mudryj. (2005) Cyclin E both regulates and is regulated by calpain 2, a protease associated with metastatic breast cancer phenotype. Cancer Research, 65, 10700-10708.
Hau Nguyen, Maria Mudryj, Moraima Guadalupe and Satya Dandekar. (2003) Hepatitis C virus core protein expression leads to biphasic regulation of the p21 cdk inhibitor and modulation of hepatocyte cell cycle. Virology 312, 245-253.
Dhillon, N.K., and M. Mudryj. (2003) Cyclin E overexpression enhances cytokine-mediated apoptosis in MCF7 breast cancer cells. Genes and Immunity 4, 336-342.
Dhillon, N.K., and M. Mudryj. (2002) Ectopic expression of cyclin E in estrogen responsive cells abrogates antiestrogen mediated growth arrest. Oncogene 21:4626-34.
Ndolo, T., N.K. Dhillon, H. Nguyen, M. Guadalupe, M. Mudryj, and S. Dandekar. (2002) Simian immunodeficiency virus nef protein delays the progression of CD4+ T cells through G1/S phase of the cell cycle. Journal of Virology 76:3587-3595.
DeBorja, P., Collins, N.K., Du, P., Azizkhan-Clifford, J.C., Mudryj, M. (2001) Cyclin A/CDK2 phosphorylates Sp1 and enhances Sp1 mediated transcription. The EMBO Journal 20:5737-5747.
Tepper CG, Seldin MF and M Mudryj. (2000) Fas mediated apoptosis of proliferating, growth arrested and senescent normal human fibroblasts. . Experimental Cell Research. 260:9-19
Research Interests:
Prostate Cancer; Breast Cancer; Cell cycle; tumor suppressors; oncogenic transformation; Signaling pathways.
Teaching Interests:
Oncogenes and tumor suppressors. Cell cycle. Virology. Genetics.