Faculty Profile

Hongwu Chen
Associate Professor of Med:Biochemisrty & Mol Medicine
Biochemistry and Molecular Medicine (School of Medicine)
UCDMC Res III, Rm 1400B
Office 916-734-7743
Lab 916-734-3221
hwzchen@ucdavis.edu
[Picture of Hongwu Chen]

Degrees:
1999 - - post-doctoral fellow - The Salk Institute for Biological Studies/HHMI, San Diego, CA. Ronald M. Evans' Laboratory
1994 - - - Ph.D. - University of California, Davis

Awards:
American Cancer Society Fellowship, 1997

Department and Center Affiliations:
UCD Cancer Center
Department of Med Biochemsitry & Molecular Medicine

Professional Societies:
American Association for Cancer Research
The Endocrine Society

Grad Group Affiliations and Specialties:
Biochemistry and Molecular Biology
Genetics
Non-DBS Grad Group(s) - Pharmacology & Toxicology

Publications:
Zou JX, Revenko AS, Li LB, Gemo AT, Chen HW. ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ER{alpha}, is required for coregulator occupancy and chromatin modification. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18067-18072.

Louie MC, Revenko AS, Zou JX, Yao J, Chen HW. Direct control of cell cycle gene expression by proto-oncogene product ACTR, and its autoregulation underlies its transforming activity. Mol Cell Biol. 2006, 26(10):3810-23.

Louie MC, Zou JX, Rabinovich A, Chen HW. ACTR/AIB1 functions as an E2F1 coactivator to promote breast cancer cell proliferation and anti-estrogen resistance. Mol. Cell. Biol. 2004, 24(12):5157-5171.

Louie MC, Yang HQ, Ma AH, Xu W, Zou JX, Kung HJ, Chen HW. Androgen-induced recruitment of RNA polymerase II to a nuclear receptor-p160 coactivator complex. Proc Natl Acad Sci U S A. 2003. 100(5):2226-2230.

Xu, W., Chen, H., Du, K., Asahara, H., Tini, M., Emerson, B.M., Montminy, M., and Evans, R.M. A transcriptional switch mediated by cofactor methylation. Science. 2001. 294(5551):2507-11.

Chen, H., Tini, M., and Evans, R.M.. 2001. HATs on and beyond chromatin. Curr. Opin. Cell Biol.. Vol 13:218-224

Research Interests:
Role and molecular mechanisms of steroid receptors (estrogen receptors and androgen receptor) and their associated chromatin coregulators in cancers (breast cancer and prostate cancer). Moleulcar mechanisms of oncogene action in cancer. Chromatin modifications/remodeling and epigenetic regulation in control of gene expression. Molecular mechanism of hormone signaling in control of cell proliferation and differentiation in the mammalian endocrine systems.

Laboratory Personnel:
Research III Bldg., Room 1204, UC Davis Medical Center - Li (Batuloo) Li, postdoc; Alexey Revenko, Graduate student (PTX); Elaine Chu, Graduate student (BMB); Ektarina Kalashnikova, Gradudate student (BMB); Maggie Louie, Graduate student (BMB, 2000-2004); Abigael Gemo, Junior Specialist.

Teaching Interests:


Regulation of gene expression; Molecular and cellular biology of endocrine-related cancer

Courses Taught:
BMB 221C Molecular Genetics
GGG 201C Miolecular Genetics
MCB 200B Molecular Biology Techniques
BCM 410A Molecular & Cellular Biology