Faculty Profile

Tzipora Goldkorn

Internal Medicine: Pulmonary/Critical Care Division (School of Medicine)

Office
Lab
ttgoldkorn@ucdavis.edu
 

Degrees:
0 - PhD - -

Department and Center Affiliations:
Cancer Center

Professional Societies:
AACR; ASCB

Grad Group Affiliations and Specialties:
Biochemistry and Molecular Biology
Non-DBS Grad Group(s) - PTX Immunology

Publications:
-Ravid T, Tsaba A, Gee P, Rasooly R, Medina EA, Goldkorn T (2003). Ceramide accumulation precedes caspase-3 activation during apoptosis of A549 human lung adenocarcinoma cells. Am J Physiol Lung Cell Mol Physiol. 284(6):L1082-1092. -Goldkorn T, Ravid T, Medina EA (2003). Ceramide signaling under oxidative stress. In: Forman HJ, Fukuto J, Torres M, editors. Signal transduction by reactive oxygen and nitrogen species: Pathways and Chemical Principles. Kluwer. March 2003. -Ravid T, Sweeney C, Gee P, Carraway KL 3rd, Goldkorn T (2002). Epidermal Growth Factor Receptor activation under oxidative stress fails to promote c-Cbl mediated down regulation. J Biol Chem. 277: 31214-31219. -Lavrentiadou SN, Chan C, Kawcak T, Ravid T, Tsaba A, van der Vliet A, Rasooly R, Goldkorn T (2001). Ceramide-mediated apoptosis in lung epithelial cells is regulated by glutathione. Am J Respir Cell Mol Biol. 25: 676-684. -Goldkorn T, George J. Lavrentiadou SN, Ravid T, Tsaba A, Shoenfeld Y, Harats D (2001). Ceramide pathway and apoptosis in autoimmunity and atherosclerosis. In: Shoenfeld Y., Harats D and Wick G editors. Atherosclerosis and Autoimmunity. Elsevier Science, Amsterdam, The Netherlands. 55-72. -Barak A., Morse LS, Goldkorn T (2001). Ceramide: a potential mediator of apoptosis in human retinal pigment epithelial cells. Invest. Ophthalmol. Vis Sci. 42 (1): 247-254.

Research Interests:
Stress modulation of tyrosine kinase receptors, ceramide/sphingomyelin pathway and apoptosis. · Mechanisms of activation and down-regulation of membrane receptor tyrosine kinase (RTK) trafficking and signaling. · The proteasome mechanism and membrane RTK degradation. · Ceramide/sphingomyelin pathway and apoptosis. · Molecular characterization (cloning and purification) of the lung nSMase. · Ceramide mechanistic interactions with Bcl2, caspases and mitochondria in lung epithelial cells. · Ceramide target genes (microarrays).