Faculty Profile

Kermit Carraway
Professor
Biochemistry and Molecular Medicine (School of Medicine)
Co-director, Breast Cancer Program, UC Davis Cancer Center
Research Bldg. III, Room 1100B, UCDMC
Office (916) 734-3114
Lab (916) 734-0190
klcarraway@ucdavis.edu
[Picture of Kermit Carraway]

Degrees:
1992 - PhD - Cornell University - Biochemistry, Cell and Molecular Biology
1985 - BS - University of Illinois - Biochemistry

Department and Center Affiliations:
UC Davis Cancer Center
Med Biochemistry and Molecular Medicine

Grad Group Affiliations and Specialties:
Biochemistry and Molecular Biology
Non-DBS Grad Group(s) - Pharmacology and Toxicology

Publications:
Carraway, K.L., III, Weber, J.L., Unger, M.J., Ledesma, J., Yu, N., Gassmann, M., and Lai, C. 1997. Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. Nature 387, 512-516.

Carraway, K.L., III, and Sweeney, C. 2001. Localization and modulation of ErbB receptor tyrosine kinases. Curr. Opin. Cell Biol. 13, 125-130.

Diamonti, A.J., Guy, P.M., Ivanof, C., Wong, K., Sweeney, C. and Carraway, K.L., III. 2002. An RBCC protein implicated in maintenance of neuregulin receptor levels. Proc. Natl. Acad. Sci. USA 99, 2866- 2871.

Wu, X., Yen, L., Irwin, L., Sweeney, C., and Carraway, K. L., III. 2004. Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. Mol. Cell. Biol. 24, 7748-7757.

Funes, M., Miller J.K., Lai, C., Carraway, K.L. III, and Sweeney C. 2006. The Mucin Muc4 potentiates Neuregulin signaling by increasing the cell surface populations of ErbB2 and ErbB3. J. Biol. Chem. 281, 19310-19319.

Sweeney, C., Miller, J.K., Shattuck, D.L., and Carraway K.L. III. 2006. ErbB receptor negative regulatory mechanisms: implications in cancer. J. Mammary Gland Biol. Neoplasia 11, 89-99.

Carraway, K.L., III, and Sweeney, C. 2006. Co-opted integrin signaling in ErbB2 induced mammary tumor progression. Cancer Cell 10, 93-5.

Yen, L., Cao, Z., Wu, X., Ingalla, E., Baron, C., Young, L., Gregg, J.P., Cardiff, R.D., Borowsky, A.D., Sweeney, C. and Carraway, K.L., III. 2006. Loss of Nrdp1 enhances ErbB2-ErbB3 dependent breast tumor cell growth. Cancer Res. 66, 11279-86.

Carraway, K.L., III, Funes, M., Workman, H.C., and Sweeney, C. 2007. Contribution of membrane mucins to tumor progression through modulation of cellular growth signaling pathways. Curr. Topics Dev. Biol. 78, 1-22.

Cao, Z., Wu, X., Yen, L., Sweeney, C. and Carraway, K.L., III. 2007. Neuregulin induced ErbB3 down-regulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1. Mol. Cell. Biol. 27, 2180-2188.

Fry, W.H., Kotelawala, L., Sweeney, C., Carraway. K.L., III. 2009. Mechanisms of ErbB receptor negative regulation and relevance in cancer. Exp. Cell Res. 68, 8286-8294.

Workman, H.C., Sweeney, C., and Carraway, K.L., III. 2009. The membrane mucin Muc4 inhibits apoptosis induced by multiple insults via ErbB2-dependent and ErbB2-independent mechanisms. Cancer Res. 69, 2845-2852.

Research Interests:
Roles of mammalian growth factors and receptor tyrosine kinases in development and tumor progression; intracellular signal transduction pathways; receptor trafficking and degradation; regulation of protein degradation by ubiquitin ligases and deubiquitinating enzymes

Teaching Interests:


Cancer biology; cell biology and metabolism

Courses Taught:
MCB 257 Cell proliferation and cancer genes - Term(s): Fall
BCM 410B Med Cell Biology and Metabolism - Term(s): Winter
BCM 410A Med Biochemistry - Term(s): Fall