Faculty Profile

Colleen Sweeney
Associate Professor and Co-director of the Breast Cancer Research Program @ UC Davis Cancer Center; College Director @ UCDSOM
Biochemistry and Molecular Medicine (School of Medicine)
Research Bldg. III, Room 1100A, UC Davis Medical Center, Sacramento
Office 916-734-0726
Lab 916-734-4747
casweeney@ucdavis.edu
[Picture of Colleen Sweeney]

Degrees:
1996 - - Harvard Medical School - Postdoctoral Fellow
1995 - PhD - Tufts University School of Medicine - Biochemistry
1990 - BS - University of Massachusetts - Chemistry/Biochemistry

Awards:
1987 Merck Index Award in Chemistry, University of Massachusetts; 1988 Louis Fenaux Award in Chemistry, University of Massachusetts; 1989 Kenneth A. Rose Award in Chemistry, University of Massachusetts; 1989 American Institute of Chemists Award; 1994 Charlton Research Poster Competition - First Place, Tufts University School of Medicine; 1994 Berlex BioSciences Predoctoral Fellowship; 1996 National Institutes of Health Postdoctoral Fellowship; 1999 Massachusetts Department of Public Health Breast Cancer Award; 2001 California Breast Cancer Research Program New Investigator Award.; 2002 California Tobacco Related Diseases Research Program New Investigator Award; 2002 UC Davis Cancer Center Annual Research Symposium, Anne Kathryn Trelford Bell Award
2004 Anne Kathryn Trelford Bell Award/UC Davis Cancer Center Research Symposium
2005 UC Davis Health System Award
2006 UC Davis School of Medicine Excellence in Education Award
2008 Kaiser Award for Excellence in Teaching Basic Sciences

Department and Center Affiliations:
Cancer Center
Biochemistry and Molecular Medicine

Professional Societies:
American Association for Cancer Research, Active Member
International Association of Medical Science Educators

Grad Group Affiliations and Specialties:
Biochemistry and Molecular Biology
Cell and Developmental Biology
Non-DBS Grad Group(s) - Comparative Pathology

Publications:
Sweeney, C., Lai, C., Riese, D.J., II, Diamonti, A.J., Cantley, L.C. and Carraway, K.L., III.. 2000. Ligand discrimination in signaling through an ErbB4 receptor homodimer. . J. Biol. Chem.. 275:19803-19807

Sweeney, C., and Carraway, K.L., III.. 2000. Ligand discrimination by ErbB receptors: differential signaling through differential phosphorylation site usage . Oncogene. 19:5568-5573

Sweeney, C., Fambrough, D.M., Huard, C., Diamonti, A.J., Lander, E.S., Cantley, L.C. and Carraway, K.L., III. . 2001. Growth factor-specific signaling pathway stimulation and gene expression mediated by ErbB receptors.. J. Biol. Chem.. 276:22685-22698

Carraway, K.L., III, and Sweeney, C. 2001. Localization and modulation of ErbB receptor tyrosine kinases. Curr. Opin. Cell Biol. 13, 125-130

Ravid, T., Sweeney, C., Carraway, KL.III, Goldkorn, T. 2002. EGF receptor activation under oxidative stress fails to promote c-Cbl mediated down regulation. J. Biol Chem. 277, 31214-9

Diamonti, A.J., Guy, P.M., Ivanof, C.,Wong, K., Sweeney, C. and Carraway, K.L. III. 2002. An RBCC Protein Implicated in Maintenance of Steady-State Neuregulin Receptor Levels. PNAS 202, 2866 – 2871

Carraway, K.L., III and Sweeney, C. 2002. EGF receptor Activation by Heterologous Mechanisms. Cancer Cell, 1, 1-2

Wu, X., Obata, T., Khan, Q., Highshaw, R.A., de Vere White, R. and Sweeney, C. 2004 The PI-3 Kinase Pathway Regulates Bladder Cancer Cell Invasion. British Journal of Urology, 93: 143-150.

Sweeney C, Carraway KL 3rd. 2004. Negative regulation of ErbB family receptor tyrosine kinases. British Journal of Cancer 90(2):289-93.

Wu, X., Yen, L., Irwin, L., Sweeney, C. and Carraway, K.L. III Stabilization of the E3 Ubquitin Ligase Nrdp1 by the Deubquitinating Enzyme Usp8. 2004 Molecular and Cellular Biology, 24(17), 7748-7757.

Laederich, M.B., Funes-Duran, M., Yen, L., Ingalla, E., Wu, X., Carraway K.L. III and Sweeney C. The Leucine-rich repeat protein Lrig1 is a negative regulator of ErbB family receptor tyrosine kinases. 2004 The Journal of Biological Chemistry, 279(45):47050-6.

Funes, M., Miller J.K., Lai, C., Carraway, K.L. III, and Sweeney C.. 2006 The Mucin Muc4 potentiates Neuregulin signaling by increasing the cell surface populations of ErbB2 and ErbB3. Journal of Biological Chemistry, 281(28): 19310-19319.

Sweeney, C., Miller, J.K., Shattuck, D.L., and Carraway K.L. III 2006. ErbB Receptor Negative Regulatory Mechanisms: Implications in Cancer. Journal of Mammary Gland Biology and Neoplasia, 11(1):89-99.

K.L. Carraway III and Sweeney, C. 2006. Co-opted integrin signaling in ErbB2 induced mammary tumor progression. Cancer Cell, 10(2):93-5.

Yen, L., Cao, Z., Wu, X., Ingalla, E., Baron, C., Young, L., Gregg, J.P., Cardiff, R.D., Borowsky, A.D., Sweeney, C. and Carraway K.L III. 2006. Loss of Nrdp1 enhances ErbB2-ErbB3 dependent breast tumor cell growth. Cancer Research 66(23):11279-86.

Carraway, K.L. III, Funes, M., Workman, H.C., and Sweeney, C. 2007. Contribution of Membrane Mucins to Tumor Progression through Modulation of Cellular Growth Signaling Pathways. Current Topics in Developmental Biology 78: 1-22.

*Shattuck, D.L., *Miller, J.K., Laederich, M., Funes, M., Petersen, H., Carraway, K.L, and Sweeney C. Lrig1 is a novel negative regulator of the Met receptor tyrosine kinase and opposes Met & Her2 synergy. Molecular and Cellular Biology 2007 March 27(5):1934-46. *co-first authors

Cao, Z., Wu, X., Yen, L., Sweeney, C. and Carraway, K.L. III. Neuregulin induced ErbB3 down-regulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1. Molecular and Cellular Biology 2007 March 27(6):2180-8.

Shattuck, D.L., Miller, J.K. Carraway, K.L. III and Sweeney, C. The Met Receptor Contributes to Trastuzumab Resistance of Her2 overexpressing breast cancer cells. 2008. Cancer Research 68: 1471-1477.

Stutz, M.A., Shattuck, D.L., Laederich, M.B., Carraway, K.L. III and Sweeney, C. LRIG1 negatively regulates the oncogenic EGF receptor mutant EGFRvIII. 2008. Oncogene, 27(43):5741-52.

Miller, J.K., Shattuck, D.L., Ingalla, E.Q., Yen, L., Young, L.G.T., Borowsky, A.D., Cardiff, R.D., Carraway, K.L. III and Sweeney, C. Suppression of the negative regulator LRIG1 contributes to ErbB2 overexpression in breast cancer. 2008. Cancer Research, Oct 15;68(20):8286-94.

Fry, W.H.D., Kotelawala, L., Sweeney, C. and Carraway K.L. III. Mechanisms of ErbB receptor negative regulation and relevance in cancer. 2008 Experimental Cell Research, in press

Workman, H.C., Sweeney, C. and Carraway K.L. III. 2009 The membrane mucin Muc4 inhibits apoptosis induced by multiple insults via ErbB2-dependent and -independent mechanisms. Cancer Research, 69(7):2845-52.

Trainor, B.C., Sweeney, C. and Cardiff, R.D. Isolating the effects of social interactions on cancer biology. 2009 Cancer Prevention Research, in press

Khan, I.H., Zhao, J., Ghosh, P., Ziman, M., Sweeney, C., Kung, H.J., and Luciw, P.A. Multiplex Microbead Suspension Arrays for Simultaneous Analysis of ErbB Family of Receptor Tyrosine Kinases: Activation and Dimerization Studies in Breast Cancer Cells. 2009 ASSAY and Drug Development Technologies, in press

Workman, H.C., Miller,J.K., Ingalla, E.Q., Kaur, R.P., Yamamoto, D.I., Beckett, L.A., Young, L.G.T., Cardiff, R.D., Borowsky, A.D., Carraway, K.L., Sweeney, C. and Carraway, K.L. III. The Membrane Mucin MUC4 is Elevated in Breast Tumor Lymph Node Metastases Relative to Matched Primary Tumors and Confers Aggressive Properties to Breast Cancer Cells. Under Revision, Breast Cancer Research.

Shattuck, D.L., Fry, W.H., Carraway, K.L. III and Sweeney, C. Lrig1 opposes ErbB2 recycling and promotes ErbB2 lysosomal degradation. Submitted, Molecular & Cellular Biology.

Research Interests:
Role of receptor tyrosine kinases in the genesis and progression of breast tumors; tumor suppressor proteins and their mechanisms of action, mechanisms of therapeutic resistance to targeted agents, role of the ZNF217 transcription factor in breast tumor initiation and progression.

Laboratory Personnel:
Sweeney laboratory Research III UC Davis Medical Center - Colleen Sweeney, Ph.D. (Principal Investigator), Francisco Mercado (graduate student), Hanine Rafidi (graduate student), Catalina Simion (graduate student), Carly Todd (graduate student), Chao Zhu (graduate student), Kimberly Yu (medical student), Sheryl Krig, Ph.D. (project scientist), Lakmal Kotelawala, Ph.D. (postdoctoral fellow), Suwanna Semsri (visiting PhD student), Manjinder Kaur (post-bac researcher).

Teaching Interests:


Regulation of cell growth and perturbation in the disease state; metabolism & inborn errors of metabolism, team based learning and other non-lecture based formats of teaching.

Courses Taught:
IMD 405 Metabolism, Endocrinology, Reproduction & Nutrition - MERN - Term(s): Winter
MDS 430 Applications of Medical Principles - Term(s): Fall,Spring