Faculty Profile

Nobuko Hagiwara
Assistant Professor
Internal Medicine: Division of Cardiovascular Medicine (School of Medicine)
Rowe Program in Human Genetics
Tupper Hall 4446
Office 752-0389
Lab 752-0955
nhagiwara@ucdavis.edu
[Picture of Nobuko Hagiwara]

Degrees:
1995 - PhD - University of Tokyo - Molecular Biology
1987 - MS - Ochanomizu Women's University - Genetics
1984 - BS - Ochanomizu Women's University - Biology

Department and Center Affiliations:
Internal Medicine, Division of Cardiovascular Medicine and Rowe Program in Human Genetics

Professional Societies:
American Heart Association, Society for Neuroscience, International Mammalian Genome Society, Society for Developmental Biology

Grad Group Affiliations and Specialties:
Biochemistry and Molecular Biology
Cell and Developmental Biology
Genetics

Publications:
Hagiwara, N., Yeh M, and Liu A. (2007) Sox6 is required for normal fiber type differentiation of fetal skeletal muscle in mice. Dev. Dynamics 236: 2062-2076

Yi, Z., Cohen-Barak, O., Hagiwara, N., Kingsley, P.D., Fuchs, D.A., Erickson, D.T., Epner, E.M., Palis, J., and Brilliant, M.H. (2006) Sox6 directly silences epsilon globin expression in definitive erythropoiesis. PLoS Genetics 2: e14

Hagiwara, N., Ma, B., and Ly, A. (2005) Slow and fast fiber isoform gene expression is systematically altered in skeletal muscle of the Sox6 mutant, p100H. Dev. Dynamics 234:301-311

Hagiwara, N., Katarova, Z., Siracusa, L.D., and Brilliant, M.H. (2003) Non-neuronal expression of the GABAA beta3 subunit gene is required for normal palate development in mice. Dev. Biol. 254:93-101.

Cohen-Barak, O., Yi, Z., Hagiwara, N., Monzen, K., Komuro, I., and Brilliant, M. H. (2003) Sox6 regulation of cardiac myocytes development. Nuc. Acids Res. 31: 5941-5948.

Cohen-Barak, O, N Hagiwara, MF Arlt, JP Horton, and MH Brilliant. (2001) Cloning, characterization and chromosome mapping of the human SOX6 gene. Gene. 265:157-164

Hagiwara, N., SE Klewer, RA Samson, DT Erickson, MF Lyon and MH Brilliant. (2000) SOX6 is a candidate gene for p100H myopathy, heart block and sudden neonatal death. Proc. Natl. Acad. Sci. USA. 97:4180-4185

Research Interests:
The Hagiwara lab studies development of the heart and skeletal muscle at the molecular and cellular levels. Currently, we are using a mouse model which is deficient of the Sox6 transcription factor. Sox6 null mice suffer from cardiac and skeletal muscle degeneration, arrhythmia, and survive no longer than 2 weeks after birth. We are researching the Sox6 mutant heart to understand the progression of early stages of heart failure. Another interesting phenotype of Sox6 null mice we have observed is fiber type distortion in skeletal muscle. Since specialization of slow- and fast-twitch fiber type is crucial for physiological function of skeletal muscle, Sox6 should play an important role in normal fetal muscle development as well as in muscle degenerative diseases. To understand the role of Sox6 in skeletal muscle development, we are investigating downstrem targets and cofactors of the Sox6 protein. To conduct our research, we utilize genetic, molecular and cellular biology techniques.

Laboratory Personnel:
Hagiwara Lab/ Tupper 4433 - Yao Dong Research Assistant, Ed Ganio Graduate Student (GGG), Minhan Dinh Undergraduate Intern, Tomoko Hiroki Post Doc

Teaching Interests:


Genetics, mammalian development

Courses Taught:
GGG 211 Concepts in Human Genetics and Genomics
GGG 294 Seminar in Human Genetics