Faculty Profile
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Su Hao Lo
Professor Biochemistry and Molecular Medicine (School of Medicine) Center for Tissure Regeneration and Repair Research I/UCDMC Office (916)734-3656 Lab shlo@ucdavis.edu |
Degrees:
1993 - PhD - Harvard University - Cell and Developmental Biology
1986 - BS - National Taiwan University -
Awards:
Shriners Hospitals Research Award (2003-2008)
Joan Oettinger Memorial Award (2008)
Department and Center Affiliations:
Biochemistry and Molecular Medicine; Orthopeadic surgery; Center for Tissue Regeneration and Repair; Cancer Center
Professional Societies:
American Society of Cell Biology
American Association for the Advancement of Science
European Life Scientist Organization
Society for Basic Urologic Research
Grad Group Affiliations and Specialties:
Biochemistry and Molecular Biology
Cell and Developmental Biology
Non-DBS Grad Group(s) - PTX, Comparative pathology
Publications:
Chen, H. Duncan, I. C. Bozorgchami, H. and Lo, S. H. Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration. Proc. Natl. Acad. Sci. USA 2002, 99:733-738.
Lo, S. H. and Lo, T. B. CTEN, a C-terminal tensin-like protein with prostate restricted expression, is down regulated in prostate cancer. Cancer Res. 2002, 62:4217-4221.
Chen, H. and Lo, S. H. Regulation of tensin-promoted cell migration by its focal adhesion-binding and Src Homology 2 domains. Biochem J. 2003, 370:1039-1045.
Lo, S. H. Molecules in focus: Tensin. Int J Biochem Cell Biol. 2004, 36:31-34.
Cui, Y., Liao, Y.C. and Lo, S. H. Epidermal growth factor modulates tyrosine phosphorylation of a novel tensin family member, tensin3. Mol Cancer Res. 2004, 2:225-232.
Chiang, M. K., Liao, Y. C., Kuwabara, Y, and Lo, S. H. Targeted disruption of tensin3 in mice results in growth retardation and postnatal lethality. Dev. Biol. 2005, 279:368-377.
Lo, S. S., Lo, S. H., and Lo, S. H. Cleavage of cten by caspase 3 during apoptosis. Oncogene. 2005, 24:4311-4314.
Chen, N. T., and Lo, S. H. The N-terminal half of talin2 is sufficient for mouse development and survive. Biochem Biophys Res Commun. 2005, 337:670-676.
Lo, S. H. Focal adhesions: what’s new inside. Dev. Biol. 2006, 294:280-91
Liao, Y.C., Si, L., deVere White, R., and Lo, S. H. The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1. J Cell Biol. 2007, 176:43-49
Lo, S. H. Reverse interactomics: from peptides to proteins and to function. AC Chem. Biol. 2007, 2:93-95.
Katz, M., Amit, I., Citri, A., Shay, T., Carvalho, S., Lavi, S., Milanezi, F., Lyass, L., Amariglio, N., Jacob-Hirsch, J., Ben-Chetrit, N., Tarcic, G., Lindzen, M., Avraham, R., Liao, Y. C., Trusk, P., Lyass, A., Rechavi, G., Spector, N. L., Lo, S. H., Schmtt, F., Bacus, S. S., Yarden, Y. A reciprocal tensin3-cten switch mediates EGF-driven mammary cell migration. Nat Cell Biol. 2007, 9:961-969.
Liao, Y. C. and Lo, S. H. Deleted in Liver Cancer-1 (DLC-1): a tumor suppressor not just for liver. Int J Biochem Cell Biol. 2008, 40:834-847
Liao, Y. C., Shih, I. P., and Lo, S. H. Mutations in DLC-1’s focal adhesion targeting region attenuated its expression and function. Cancer Res 2008, 68:7718-7722
Hsieh S. C., Chen, N. T., Lo, S. H. Conditional loss of PTEN leads to skeletal abnormalities and lipoma formation. Mol Carcinog. 2009, 48:545-552
Lulevich, V., Shih, I. P., Lo, S. H., and Liu, G. Y. Cell tracing dyes significantly change single cell mechanics. J Phys Chem 2009, 113:6511-6519
Liao, Y. C., Chen, N. T., Shih Y. P., Dong, Y., Lo, S. H. Up-regulation of C-terminal tensin-like molecule promotes the tumorigenicity of colon cancer cells through beta-catenin. Cancer Res 2009, 69:4563- 4566
Research Interests:
Cell-cell and cell-matrix junctions, focal adhesions, cytoskeleton, signal transduction, tensin, animal models for human diseases.
http://www.ucdmc.ucdavis.edu/ctrr/research/lo.html
Laboratory Personnel:
Irene Shih, - PhD
Nien-Tsu Chen, MS
Wenming Gao ??
Yi-Chun Liao, PhD
Yuan Lin, MD