Faculty Profile

Charles L. Bevins
Professor of Microbiology and Immunology
Microbiology and Immunology (School of Medicine)
GBSF, Room 5617
Office 530.754.6889
Lab 530.754.6679
CLBevins@ucdavis.edu
[Picture of Charles L. Bevins]

Degrees:
1986 - PhD - University of Maryland - Biochemistry
1983 - MD - University of Maryland - Medicine
1976 - BA - Universty of Maryland, Baltimore County - Biological Sciences

Department and Center Affiliations:
Medical Microbiology and Immunology
Associate Director, MD-PhD Program

Professional Societies:
American Association for the Advancement of Science
American Society for Microbiology
American Association of Immunology
American Gastroenterological Association
Fellow, American College of Gastroenterology
American Society for Human Genetics
Society for Pediatric Research

Grad Group Affiliations and Specialties:
Biochemistry and Molecular Biology
Microbiology
Non-DBS Grad Group(s) - Immunology, Comparative Pathology

Publications:
Hornsby, MJ, Huff, JL, Kays, RJ, Canfield, DR, Bevins, CL and Solnick, JV Helicobacter pylori induces an antimicrobial host response in rhesus macaques in a Cag Pathogenicity Island-Dependent Manner Gastroenterology 134:1049-1057, 2008.

Bevins, CL and Liu, F-T Rosacea: Skin innate immunity gone awry? Nat. Medicine 13: 904-905, 2007

Baumgarth, N and Bevins, CL, Skin deep but complex. Nature 449:551-553, 2007.

Wehkamp, J, Wang, G, Kübler, I, Schaeffeler, E, Nuding, S, Gregorieff, A, Schnabel, Kays, RJ, Reinisch, W, Teml,, A, Vermeire, S, Rutgeerts, P, Fellermann, K, Burk, O, Clevers, H, Schwab, M, Bevins, CL and Stange, EF. The Paneth Cell alpha-Defensin Deficiency of Ileal Crohn´s Disease is Linked to Wnt/Tcf-4. J. Immunol. 179:3109-3118, 2007.

Raffatellu, M, Santos, RL, Chessa, D, Wilson, RP, Winter, S, Rossetti, CA, Lawhon, SD, Chu, H, Lau, T, Bevins, CL, Adams, LG, and Baümler, AJ, The Capsule Encoding the viaB Locus Reduces Interleukin-17 Expression and Mucosal Innate Responses in the Bovine Intestinal Mucosa during Infection with Salmonella enterica Serotype Typhi. Infect. Immun. 75: 4342-4350, 2007.

Wehkamp, J, Chu, H, Shen, B, Feathers, RW, Kays, RJ, Lee, SK, and Bevins, CL, Paneth Cell Antimicrobial Peptides: Topographical Distribution and Quantification in Human Gastrointestinal Tissues. FEBS Lett. 580: 5344-5350, 2006.

McGillivary, G., Ray, W.C., Bevins, C.L., Munson Jr., R.S., Bakaletz, L.O., A member of the cathelicidin family of antimicrobial peptides is produced in the upper airway of the chinchilla and its mRNA expression is altered by common viral and bacterial co-pathogens of otitis media. Molec. Immunol. 44: 2446-2458, 2007.

Salzmann, NH, Underwood, MA, and Bevins CL, Paneth Cells, Defensins, and the Commensal Microbiota: A hypothesis on intimate interplay at the intestinal mucosa. Seminars in Immunology 19: 70-83, 2007.

Wehkamp, J., Salzman, N. H., Porter, E., Weichenthal, M., Petras, R. E., Shen, B., Schaeffeler, E., Schwab, M., Linzmeier, R., Feathers, R. W., Chu, H., Lima, J., H., Fellermann, K., Ganz, T., Stange, E. F. and Bevins, C. L.: Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A 102, 18129-18134, 2005.

Wehkamp, J, Fellermann, K, Herrlinger, K, Bevins, CL and Stange EF, Defensins in gastrointestinal diseases, Nature Clin. Practice (Gastroenterology and Hepatology) 2:406-415, 2005.

Bevins, CL, An important clue: fingerprints point to psoriasin in defense against E. coli. Nat Immunol 6: 12-13, 2005.

Sherman, MP, Bennett, SH, Hwang, FFY, Sherman, J, and Bevins, CL: Paneth Cells and Antibacterial Host Defense in Neonatal Small Intestine. Infect. Immun. 73:6143-6146, 2005.

Salzman, N., Ghosh, D., Huttner, K.M. Paterson, Y. and Bevins, C.L. Human defensin-5 gene in transgenic mice: Paneth cell specific expression and protection from lethal Salmonella typhimurium infection. Nature 422:522-526, 2003.

Ghosh, D., Porter, E.M., Shen, B., Lee, S.K., Wilk, D.J., Crabb, J.W., Drazba, J., Yadav, S.Y., Ganz, T. and Bevins, C.L. Paneth cell trypsin is the processing enzyme for human defensin-5. Nat. Immunol. 3:583-590, 2002.

Jia, H.-P., Wowk, S.A., Schutte, B.C., Lee, S.K., Vivado, A., Tack, B.F., Bevins, C.L., and McCray, Jr. P.B., A novel murine b-defensin expressed in tongue, esophagus and trachea. J. Biol. Chem. 275:33314-33320, 2000.

Diamond, G, Kaiser, V, Rhodes, J, Russell, J, and Bevins, C, Transcriptional regulation of b-defensin gene expression in tracheal epithelial cells. Infect Immun 68: 113-119., 2000.

Yount, N.Y., Yuan, J., Tarver, A.P., Diamond, G., Levy, J.N., McGuire, P.A., McCullogh, C., Cullor, J.S., Bevins, C.L., and Selsted, M.E.: Molecular cloning and expression of bovine neutrophil b-defensin 4. Characterization of cDNA and genomic sequences, pattern of tissue expression, and localization of the fully-processed peptide to neutrophil dense granules. J. Biol. Chem. 274: 26249-26258, 1999.

Tarver AP, Clark DP, Diamond G, Russell, J.P., Erdjument-Bromage, H., Tempst P, Cohen K, Jones, D.E., Sweeney, R.W., Wines M, Huang S and Bevins CL Enteric beta-Defensin: Molecular Cloning and Characterization of a Gene with Inducible Intestinal Epithelial Cell Expression Associated with Cryptosporidium parvum. Infection Infection and Immunity 66: 1045-56, 1998.

Diamond G., Russell J.P. and Bevins C.L.: Inducible expression of an endogenous antibiotic in lipopolysaccharide-challenged tracheal epithelial cells. PNAS 93: 5156-5160, 1996.

Mallow, E.M., Harris, A., Salzman, N., Russell, J.P., DeBerardinis, J.P., Ruchelli, E. and Bevins, C.L.: Human enteric defensins: Gene structure and developmental expression. J. Biol. Chem. 271: 4038-4045, 1996.

Research Interests:
Innate Immunity; Mucosal Host Defense; Host-Microbe Interactions; Defensins
http://www.ucdmc.ucdavis.edu/microbial/

Laboratory Personnel:
Bevins Lab/ GBSF 5617 - Mark Underwood, MD, Colby Weeks, PhD., Hiutung Chu (3rd yr grad), Joe Russell (3rd yr grad), Anchasa Kananurak (2nd yr grad), Patricia Castillo (1st yr grad) Brian Leonard (DVM/Phd Student) Bob Kays (Lab Manager), Romobia Hutchinson (undergrad). Recent Visiting Scholars: Pak-Lam Yu PhD (on sabatical), Mats Andersson PhD (on sabatical), Jan Wehkamp MD (Visiting Fellow), Jenny Karlsson (Visiting Grad Student), Björn Schröder (Visiting Grad Student)

Courses Taught:
IMM 201 Basic Immunology (Team Taught)
IMM 293 Current Concepts in Immunology (Team Taught)
IMM 297 Mucosal Immunology (Team Taught)
MMI 210 Research Journal Club (Dual Degree and T32 Students)
MMI 480A Medical Immunology (Team Taught)