Faculty Profile

Cecilia Giulivi
Professor
Molecular Biosciences (Vet Med)
1095 HARING HALL
Office +1 530 754 8603
Lab 1 530 752 1038
cgiulivi@ucdavis.edu
[Picture of Cecilia Giulivi]

Degrees:
1989 - PhD - University of Buenos Aires - Biochemistry
1985 - Diploma - University of Buenos Aires - Biochemistry

Department and Center Affiliations:
Molecular Biosciences, School of Veterinary Medicine; Member of the UC Davis Cancer Center

Professional Societies:
American Society for Biochemistry and Molecular Biology
Society for Free Radical Research

Grad Group Affiliations and Specialties:
Biochemistry and Molecular Biology

Publications:
Giulivi, C., Ross-Inta, C.M., Horton, A., and Luckhart, S. (2008) Metabolic Pathways in Anopheles stephensi mitochondria. Biochem. J., in press.

Ross-Inta, C., Tsai, C.-Y., and Giulivi, C. (2008) The mitochondrial pool of free amino acids reflects the composition of mitochondrial-DNA encoded proteins: Indication for a post-translational quality control for protein synthesis. Biosci. Reports, in press.

DiMarco, T. and Giulivi, C. (2007) Evaluation of analytical methods to detect dityrosine, a biomarker of oxidative stress, in biological samples. Mass Spec. Rev. 26, 108-120.

Miller, S., Inta-Ross, C. and Giulivi, C. (2007) Kinetic and proteomic analyses of S-nitrosoglutathione-treated hexokinase: consequences for cancer energy metabolism. Amino acids 32, 593-602.

Giulivi, C., Kato, K. And Cooper, C. E. (2006) Nitric oxide regulation of mitochondrial oxygen consumption I: cellular physiology. Am. J. Physiol. 291, 1225-1231.

Cooper CE and Giulivi, C. (2007) Nitric oxide regulation of mitochondrial oxygen consumption II: molecular mechanism and tissue physiology. Am J Physiol. 292, 1993-2003.

Kato K, Giulivi C. (2006) Critical overview of mitochondrial nitric-oxide synthase. Front Biosci. 11:2725-38.

Mazzanti, R. and Giulivi, C. (2006) Coordination of nuclear- and mitochondrial-DNA encoded proteins in cancer and normal colon tissues. Biochim Biophys Acta 1757, 618-623.

Mazzanti, R., Solazzo, M. Squires, R., Fantappie, O., Cechi, F, Bianchi, P., and Giulivi, C. (2006) Differential expression proteomics of human colon cancer. Am J Physiol 290:G1329-38.

Green, A., Rutherford, M. S., Regal, R. R., Flickinger, G. H., Hendrickson, J. A., Giulivi, C., Mohrman, M. E., Fraser, D. G., and Regal, J. F. (2005) Arginase Activity Differs with Allergen in the Effector Phase of Ovalbumin- versus Trimellitic Anhydride-Induced Asthma. Tox. Sci. 88, 420-433.

Johnson F, Giulivi C. (2005) Superoxide dismutases and their impact upon human health. Mol Aspects Med. 26, 340-352.

Oursler, M. J., Bradley, E., Elfering, S. and Giulivi, C. (2005) Native, not nitrated, cytochrome c and mitochondrial-derived hydrogen peroxide drive osteoclast apoptosis. Am., J. Physiol. 288, C156-168.

Haynes, V., Elfering, S. L., Squires, R., Traaseth, N., Solien, J., Ettl , A. and Giulivi, C. (2004) Mitochondrial Nitric-Oxide Synthase: Role in Pathophysiology. IUBMB Life 55, 599-603.

Traaseth, N, Elfering, S. L., Solien, J., Haynes, V., and Giulivi, C. (2004) Role of Calcium Signaling in the Activation of Mitochondrial Nitric-Oxide Synthase and Citric Acid Cycle. Biochim. Biophys. Acta 1658, 64-71.

Haynes, V., Elfering, S. L., Traaseth, N., and Giulivi, C. (2004) Mitochondrial Nitric-Oxide Synthase: Enzyme expression, characterization and regulation. J. Bioenerg. Biomemb. 36, 341-346.

Elfering, S. L., Haynes, V., Traaseth, N., Ettl, A. and Giulivi, C. (2004) Aspects, mechanism, and biological relevance of mitochondrial protein nitration sustained by mitochondrial nitric oxide synthase. Am. J. Physiol. 286, H22-H29.

Xiong, S., She, H., Takeuchi, H., Engelhardt, J. F., Barton, C. H., Zandi, E., Giulivi, C., and Tsukamoto, H. (2003) Signaling role of intracellular iron in NF-kB activation. J. Biol. Chem. 278, 17646-54.

Giulivi, C. (2003) Characterization and function of mitochondrial nitric-oxide synthase. Free Radical Biol. Med. 34, 397-408.

Giulivi, C, Traaseth, N. J., and Davies, K. J. A. (2003) Tyrosine oxidation products: analysis and biological relevance. Amino Acids 25, 227-232.

Elfering, S. L., Sarkela, T. M. and Giulivi, C. (2002) Biochemistry of mitochondrial nitric oxide synthase. J. Biol. Chem. 277, 38079-38086.

Sarkela, T., Berthiaume, J., Elfering, S., Gybina, A. and Giulivi, C. (2001) The modulation of oxygen radical production by endogenous nitric oxide in mitochondria. J. Biol. Chem. 276, 6945-6949.

Steffen, M., Sarkela, T.M., Gybina, A.A., Steele, T.W., Traaseth, N. J., Kuehl, D. and Giulivi, C. (2001) Metabolism of S-nitrosoglutathione in intact mitochondria. Biochem. J. 356, 395-402.

French, S., Giulivi, C., and Balaban, R. S. (2001) Nitric oxide synthase in porcine heart mitochondria: Evidence for a low physiological activity. Am. J. Physiol. 280, H2863-7.

Research Interests:
-Biosynthesis of nitric oxide in mitochondria. Role of nitric oxide produced by mitochondria in cellular oxygen metabolism and vasodilation. Mitochondrial nitric oxide synthase: regulation of expression. Biosynthesis and metabolism of endogenous nitric oxide in mammalian cells. Role of nitric oxide, superoxide anion, and peroxynitrite anion in mediating pathophysiological processes. -Mitochondrial nitrated proteins: role of nitration, metabolism of nitrated proteins, implications for pathophysiology. -Oxygen and nitrogen free radical biochemistry and chemistry in in vitro and in vivo model systems. Mechanistic aspects of oxygen and nitrogen free radical damage. -Proteomics of aging and oxidative damage of mitochondria -Functional proteomics of human colon cancer

Laboratory Personnel:
2116 Haring Hall - Ms. Catherine Ross-Inta, Yi-Fan Zhang, Jennifer Pong, Julia Overman, Sarah Wong

Teaching Interests:


Biological Chemistry; Spectroscopy; Bioenergetics; Oxygen and nitrogen free radical biochemistry.

Courses Taught:
PTX 290 Seminar - Term(s): Spring
VM 403 Physiological Chemistry - Term(s): Fall