Faculty Profile

Paramita M Ghosh
Associate Adj. Professor
Biochemistry and Molecular Medicine (School of Medicine)
MED: Urology
Research III, UC Davis Medical Center
Office +1 916 843 9336
Lab +1 916 843 7000 X16675
paghosh@ucdavis.edu
[Picture of Paramita M Ghosh]

Degrees:
1994 - PhD - Rensselaer Polytechnic Institute - Chemistry
1989 - MS - Jadavpur University, Calcutta, INDIA - Physics
1987 - BS - Jadavpur University, Calcutta, INDIA - Physics

Awards:
2000 WICR Young Investigator Scholar Award. American Association for Cancer Research
1997-1999 NIH Postdoctoral Training Award. Department of Pathology, University of Texas Health Science Center at San Antonio, TX.
1989-1994 Tuition Scholarship and Graduate Assistantship. Rensselaer Polytechnic Institute, Troy, NY
1989 Gold Medal for Excellence, Master of Science. Department of Physics, Jadavpur University, Calcutta 700032, India
1989 S.N. Bose Medal for best academic achievement. Department of Physics, Jadavpur University, Calcutta 700032, India.
1983-1989 National Science Scholarship. University Grants Commission, Government of India
2006 UC Davis Academic Federation Travel Award
2006 Best Poster Award. International Symposium on Hormonal Carcinogenesis, Montpellier, France

Department and Center Affiliations:
Department of Urology, School of Medicine
UC Davis Cancer Center
Department of Biochemistry and Molecular Medicine

Professional Societies:
American Association for Cancer Research
Society of Basic Urological Research
American Association for the Advancement of Science
American Urological Association

Grad Group Affiliations and Specialties:
Biochemistry and Molecular Biology

Publications:
Bedolla, RG, Asuncion, A, Chamie, K, Siddiqui, S, Troyer, DA, Mehra, R, Siddiqui, J, Chinnaiyan, AM, deVereWhite, RW, and Ghosh, PM. Nuclear vs Cytoplasmic localization of Filamin A in Prostate Cancer: Immunohistochemical Correlation with Metastases. Clinical Cancer Research, 15(3): 788-796. 2009.

Chamie, K, Ghosh, PM, Koppie, TM, Romero, V, Troppmann, C,and deVere White, RW. The effect of sirolimus on PSA kinetics in male renal transplant recipients without prostate cancer. American Journal of Transplantation, 8(12): 2668-2673. 2008.

Wang, Y, Mikhailova, M, deVere White, RW, and Ghosh, PM. Regulation of androgen receptor transcriptional activity by rapamycin. Oncogene, 27(56): 7106-7117. 2008

Kamat, A., Ghosh, PM, Glover, RL, Zhu, B, Yeh, CK, Choudhury, GG and Katz, MS. Reduced Expression of Epidermal Growth Factor Receptors in. Journal of Gerontology, 63(7): 683-692. 2008

Mikhailova, M., Wang, Y., Bedolla, R.G., Lu, X.H., Kreisberg, J.I. and Ghosh, P.M.: AKT Regulates Androgen Receptor-dependent Growth and PSA Expression in Prostate Cancer, Adv Exp Med Biol., Vol. 617, pp. 397-405. 2008.

Wang, Y., Kreisberg, J.I. and Ghosh, P.M. Cross-talk between the Androgen Receptor and the Phosphatidylinositol 3-kinase/Akt pathway in Androgen-Independent Prostate Cancer. Current Cancer Drug Targets. 7: 591-604. 2007

Shi, X.-B., Xue, L. Tepper, C.G., Gandour-Edwards, R., Ghosh, P., Kung, H.J. and deVere White, R.W. . The oncogenic potential of a prostate cancer-derived androgen receptor mutant. The Prostate, 67(6): 591-602. 2007.

Bedolla R, Prihoda TJ, Kreisberg JI, Malik SN, Krishnegowda NK, Troyer DA, Ghosh PM. Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation. Clin. Cancer Res., 13(13): 3860-3867. 2007

Wang, Y., Kreisberg, J.I., Bedolla, R., Mikhailova, M., deVere White, R.W. and Ghosh, P.M. A 90 kDa fragment of filamin A promotes Casodex-induced growth inhibition in Casodex-resistant androgen receptor positive C4-2 prostate cancer cells. Oncogene. 2007.

Vinall, R.L., Hwa, K., Ghosh, P., Pan, C-X., Lara, P.N. Jr. and deVere White, R.W. Combination Treatment Of Prostate Cancer Cell Lines With Bioactive Soy Isoflavones (GCP) And Perifosine Causes Increased Growth Arrest And/Or Apoptosis. Clinical Cancer Res., 13: 6204-6216, 2007

Ghosh, P.M., Malik, S.N., Prihoda, T.J., Bedolla, R.G., Wang, Y., Troyer, D.A. and Kreisberg, J.I. Akt mediates proliferation via both androgen-dependent and independent pathways in prostate cancer. Endocr Relat Cancer. Mar;12(1):119 34. 2005

Yeh, C. K.**, Ghosh, P.M.**, Liu, Q., Zhang, B. X., and Katz, M.S. Activation of Mitogen-activated Protein Kinase Mediates Isoproterenol-induced Salivary Cell Growth. Am J Physiol Cell Physiol. 288(6):C1357-C1366. 2005

Kreisberg, J.I., Malik, S.N., Prihoda, T.J., Bedolla, R.G., Troyer, D.A. Kreisberg, S. and Ghosh, P.M. Expression of phospho-AKT (Ser 473) is an excellent predictor of Poor Clinical Outcome in Prostate Cancer. Cancer Res. Aug 1;64(15):5232-6. 2004

Ghosh, P.M., Bedolla, R., Thomas, C.A. and Kreisberg, JI. Role of Protein kinase C in Arginine Vasopressin-stimulated mesangial cell proliferation. J. Cell. Biochem., 2004; 91(6):1109-29.

Ghosh, P.M., Malik, S. N., Bedolla, R. and Kreisberg, J.I. Akt in Prostate Cancer: Possible Role in Androgen-Independence. Current Drug Metabolism, 4(6):487-496. 2003

Ghosh PM, Bedolla R, Mikhailova M, and Kreisberg JI. RhoA-Dependent Murine Prostate Cancer Cell Proliferation and Apoptosis: Role of PKCzeta. Cancer Res. 62(9):2630-6. 2002

Malik, S.N., Brattain, M.G., Ghosh, P.M., Troyer, D.A., Prihoda, T., Bedolla, R. and Kreisberg, J.I. Immunohistochemical Demonstration of phospho-Akt in High Gleason Grade Prostate Cancer. Clinical Cancer Res. 8(4):1168-71. 2002

Sawhney RS, Guo-Hao K, Humphrey LE, Ghosh P, Kreisberg JI, Brattain MG: Differences in sensitivity of biological functions mediated by epidermal growth factor receptor activation with respect to endogenous and exogenous ligands. J Biol Chem 277: 75-86. 2002

Ghosh, P.M., Mikhailova, M., Bedolla, R. and Kreisberg, J.I. Arginine Vasopressin Stimulates Mesangial Cell Proliferation by Activating the Epidermal Growth Factor Receptor. Am. J. Physiol- Renal Physiology. 280(6):F972-979. 2001

Ghosh-Choudhury, N., Ghosh-Choudhury, G., Celeste, A., Ghosh, P.M., Moyer, M.L., Abboud, S.L., and Kreisberg, J.I. Bone Morphogenic Protein-2 induces cyclin kinase inhibitor p21 and hypophosphorylation of retinoblastoma protein in estradiol treated MCF- human breast cancer cells. Biochim. Biophys. Acta 1497:186-196. 2000

Ghosh, P.M., M. Moyer and J.I. Kreisberg. Effect of cyclin E overexpression on lovastatin-induced G1 arrest and RhoA inactivation in NIH3T3 cells. J. Cell. Biochem. 74: 532  543. 1999

Ghosh, P.M., G.E. Mott, M.L. Stapleton, N. Ghosh-Choudhury and J.I. Kreisberg. Role of RhoA and actin stress fiber formation in the proliferation of a mouse prostate cancer cell line. Oncogene. 18: 4120-4130. 1999

Ghosh, P., G.E. Mott, N. Ghosh-Choudhury, R.A. Radnik, M.L. Stapleton, J.J. Ghidoni and J.I. Kreisberg. Lovastatin induces apoptosis by inhibiting mitotic and post-mitotic events in cultured mesangial cells. Biochim. Biophys. Acta. 1359: 13-24. 1997

Klebe, R.J., A. Grant, G. Grant and P. Ghosh. 1995. Cyclic-AMP deficient MDCK cells from tubules. J. Cell Biochem. 59:453-462. 1995

Klebe, R.J., C.A. Thomas, G.M. Grant, A. Grant and P. Ghosh. Cytoscription: Computer-controlled micropositioning of cell adhesion proteins. J. Tissue Culture Methods. 16:189-192. 1994

Ghosh, P.M., C.R. Keese and I. Giaever. Morphological response of mammalian cells to pulsed AC fields. Bioelectrochem. Bioenerg. 33:121-133. 1994

Ghosh, P.M., C.R. Keese and I. Giaever. Monitoring Electropermeabilization in the Plasma Membrane of Adherent Mammalian Cells. Biophys. J. 64: 1602-1609. 1993

Mitra, P., C.R. Keese and I. Giaever. Electrical Measurements can be used to Monitor the Attachment and Spreading of Cells in Tissue Culture. Biotechniques. 11: 504-510. 1991

Research Interests:
My chief topic of research over the last six years has been the elucidation of signal transduction pathways leading to the development of androgen-independent prostate cancer. Prostate cancer is a disease of the aging male. In a normal adult prostate, there is a balance between the rate of proliferation and the rate of apoptosis or cell death. In prostate cancer, this balance is lost, resulting in excessive proliferation, decreased apoptosis or both. My current research is based on the initial observation from our laboratory that in poorly differentiated prostate cancers, Akt, a downstream target of the phosphatidylinositol 3-kinase (PI3K) pathway, is highly phosphorylated. Based on these observations, I have investigated, over the last few years, the role of Akt in the progression of prostate cancer to an androgen-independent state. Currently, I am engaged in studying signal transduction pathways both upstream and downstream of Akt. Upstream of Akt, I am studying the effect of receptor tyrosine kinases and their effects on both the PI3K and the MAPK cell signaling pathways, while downstream of Akt, I am studying the cross-talk with the androgen receptor pathway, and the effects of aging on the development of prostate cancer. At present, our targets of investigation include the erbB family of receptor tyrosine kinases, the andogen receptor, the cytoskeletal scaffolding molecule Filamin A which is known to be an androgen receptor coregulator and components of the signal transduction pathways downstream of Ras (including the mitogen activated protein kinases) and the mammalian target of rapamycin (mTOR), including p70 S6 kinase, 4E-BP1 and e1F-4G.

Laboratory Personnel:
VA Northern California Health Care System, Mather, CA - Liqun Chen - Graduate student; Salma Siddiqui, MBBS - Postdoctoral Associate; Swagata Bose, Ph.D. - Postdoctoral Fellow Benjamin Mooso - Junior Specialist

Teaching Interests:


Cell and Molecular Biology Biochemistry

Courses Taught:
BCM 410B Cell Biology and Metabolism - Term(s): Winter
BMB 290 Biochemistry and Molecular Biology Seminar - Term(s): Winter