Faculty Profile

Aldrin V Gomes
Asst Professor
Neurobiology, Physiology, and Behavior (College of Biological Sciences)
Physiology and Mebrane Biology
177 Briggs Hall, Davis, CA 95616
Office +1 530 752 3207
Lab +1 530 754 9548
avgomes@ucdavis.edu
http://www.npb.ucdavis.edu/labs/gomes/
[Picture of Aldrin V Gomes]
We are interested in the molecular mechanisms of signal transduction, particularly in muscle contraction and cardiovascular disease. The two main research areas in my laboratory are: the role of the proteasome in normal, protected and diseased cardiac and skeletal muscle and the role of troponin in calcium regulation of muscle contraction in hypertrophic, dilated and restrictive cardiomyopathies.

Degrees:
1998 - PhD - University of the West Indies, St. Augustine - Biochemistry

Awards:
Alpha Omega Merit Award from the University of the West Indies School of Medicine, 1995
Young Scientist Award from the International Union of Biochemistry and Molecular Biology, 1997
Biochemical Society Fellowship, 2000
American Society Biochemistry and Molecular Biology Travel Fellowship, 2000
Scientist Development Grant from the Muscular Dystrophy Association, 2002
American Heart Association Travel Award, 2004
Scientist Developmental Grant from the American Heart Association, 2008

Department and Center Affiliations:
Neurobiology, Physiology and Behavior (NPB), College of Biological Sciences
Physiology and Membrane Biology, School of Medicine

Professional Societies:
American Heart Association (AHA)
Biophysical Society
Cardiac Society
Internation Society for Heart Research
American Physiological Society

Grad Group Affiliations and Specialties:
Biochemistry and Molecular Biology
Exercise Science
Molecular, Cellular, and Integrative Physiology

Publications:
Protein Degradation

Gomes, A.V., Young, G.W., Wang, Y., Zong, C., Eghbali, M., Drews, O., Lu, H., Stefani, E., Ping, P. (2009) Contrasting proteome biology and functional heterogeneity of the 20S proteasome complexes in mammalian tissues. Mol Cell Proteomics. 8:302-15.

Mayr M., Grainger, D., Mayr, U., Leroyer, A.S., Leseche, G., Sidibe, A., Herbin, O., Yin, X., Gomes, A.V., Madhu, B., Griffiths, J.R., Xu, Q., Tedgui, A. and Boulanger, C.M. (2009) Proteomics, Metabolomics, and Immunomics on Microparticles Derived from Human Atherosclerotic Plaques. Circ. Cardiovasc. Genet. in press.

Mayr, M., Liem, D., Zhang, J., Li, X., Avliyakulov, N.K., Yang, J.I., Young, G., Vondriska, T.M., Ladroue, C., Madhu, B., Griffiths, J.R., Gomes, A., Xu, Q., Ping, P. (2009) Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts. J. Mol. Cell. Cardiol. 46:268-77.

Drews, O., Wildgruber, R., Zong, C., Sukop, U., Nissum, M., Weber, G., Gomes, A.V., Ping, P. (2007) Mammalian proteasome subpopulations with distinct molecular compositions and proteolytic activities. Mol. Cell. Proteomics 6:2021-2031.

Gomes, A.V. Zong, C., Edmondson, R., Li, X., Stefani, E., Zhang, J., Jones, R.C., Thyparambil, S., Wang, G.W., Qiao, X., Bardag-Gorce, F., Ping, P. (2006) Mapping the Murine Cardiac 26S Proteasome Complexes. Circulation Research 99:362-71.

Zong, C., Gomes, A.V. Drews, O., Li, X., Young, G.W., Berhane, B., Qiao, X., French, S.W., Bardag-Gorce, F., Ping, P. (2006) Regulation of Murine Cardiac 20S Proteasomes: Role of Associating Partners. Circulation Research 99:372-80.

Gomes, A.V. Zong, C., Ping, P. (2006) Protein Degradation by the 26S Proteasome System in the Normal and Stressed Myocardium. Antioxidants & Redox Signaling 9/10:1677-1691.

Gomes, A.V. et al., (2005) Murine Cardiac 26S Proteasome: An Organelle Awaiting Exploration. Ann N Y Acad Sci. 1047, 197-207.

Barnes, J.A,, Singh, S., Gomes, A.V. (2005) Protease activated receptors in cardiovascular function and disease. Mol. Cell Biochem. 263, 227-39.

Barnes, J.A,, Gomes, A.V. (2002) Proteolytic signals in the primary structure of annexins. Mol. Cell Biochem. 231, 1-7.

Cuervo A.M., Gomes A.V., Barnes J.A., Dice J.F. (2000) Selective Degradation of Annexins by Chaperone-mediated Autophagy. J. Biol. Chem. 275, 33329-33335.

Role of Troponins in Muscle Contraction and Disease

Lounes, K.C., Demeler, B., Anderson, D.E., Gomes, A.V., Potter, J.D., Nassar, R., Anderson, P.A. (2008) Cardiac troponin T forms a tetramer in vitro. Biochemistry. 47, 1970-6.

Wen Y, Pinto JR, Gomes AV, Xu Y, Wang Y, Wang Y, Potter JD, Kerrick WG. (2008) Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice. J Biol Chem. 283:20484-94

Gomes, A.V., Liang, J., Potter J.D. (2005). Mutations in human cardiac troponin I that are associated with restrictive cardiomyopathy affect basal ATPase activity and the calcium sensitivity of force development. J. Biol Chem. 280, 30909-15.

Gomes, A.V., Harada, K., Potter J.D. (2005). A Hypertrophic Cardiomyopathy Mutation in the N-terminal of Troponin I affects the Calcium-Sensitivity, Phosphorylation Kinetics and Proteolytic Susceptibility of Troponin. J. Mol. Cell. Cardiol. 39, 754-65.

Venkatraman, G., Gomes, A.V., Kerrick, W.G., Potter J.D. (2005) Characterization of troponin T dilated cardiomyopathy mutations in the fetal troponin isoform. J. Biol Chem. 280, 17584-92.

Gomes, A.V., Venkatraman, G., Potter, J.D. (2005) The miscommunicative cardiac cell: when good proteins go bad. Ann N Y Acad Sci. 1047, 30-7.

Gomes, A.V., Venkatraman, G., Davis, J.P., Tikunova, S.B., Engel, P., Solaro, R.J., Potter J.D. (2004) Cardiac troponin T isoforms affect the Calcium sensitivity of force development in the presence of slow skeletal troponin I: Insights into the role of troponin T isoforms in the fetal heart. J. Biol Chem. 279, 49579-87.

Venkatraman, G., Harada K., Gomes, A.V., Kerrick, W.G., Potter, J.D. (2003) Different functional properties of troponin T mutants that cause dilated cardiomyopathy. J. Biol Chem. 278, 41670-6.

Gomes, A.V., Guzman, G., Zhao, J., Potter, J.D. (2002) Cardiac troponin T isoforms affect the Calcium-sensitivity and inhibition of force development: insights into the role of troponin T isoforms in the heart. J. Biol Chem. 277, 35341-35349.

Lang, R., Gomes, A.V., Zhao, J., Housmans, P.R., Miller, T., Potter, J.D. (2002) Functional Analysis of a Troponin I (R145G) Mutation Associated with Familial Hypertrophic Cardiomyopathy. J. Biol. Chem. 277, 11670-11678.

Miller, T., Szczesna, D., Housmans, P.R., Zhao, J., de Freitas, F., Gomes, A.V., Culbreath, L., McCue, J., Wang, Y., Xu, Y., Kerrick, W.G. and Potter, J.D. (2001) Abnormal Contractile Function in Transgenic Mice Expressing an FHC-Linked Troponin T (I79N) Mutation. J. Biol. Chem. 276, 3743-3755.

Szczesna, D., Ghosh, D., Li, Q., Gomes, A.V., Guzman, G., Arana, C., Zhi, G., Stull, J.T., Potter, J.D.(2001) Abnormal Familial hypertrophic cardiomyopathy mutations in the regulatory light chains of myosin affect their structure, Calcium binding and phosphorylation. J. Biol. Chem. 276, 7086-7092.

Related Publications

Baldán A, Gomes AV, Ping P, Edwards PA. Loss of ABCG1 results in chronic pulmonary inflammation. (2008) J Immunol. 180,3560-8.

Yuan, T., Gomes, A.V., Barnes, J.A., Hunter, H.N. and Vogel, H.J. (2004) Spectroscopic characterization of the calmodulin-binding and autoinhibitory domains of calcium/calmodulin-dependent protein kinase I. Arch. Biochem. Biophys. 421, 192-206.

Gutierrez-Ford, C., Levay, K., Gomes, A.V., Perera, E.M., Som, T., Kim, Y.M., Benovic J.L., Berkovitz G.D., Slepak V.Z. (2003) Characterization of Tescalcin, a Novel EF-Hand Protein with a Single Calcium-Binding Site: Metal-Binding Properties, Localization in Tissues and Cells, and Effect on Calcineurin. Biochemistry 42, 14553-14565.

Gomes A.V., Barnes J.A., Vogel H.J. (2000) Spectroscopic characterization of the interaction between calmodulin-dependent protein kinase I and calmodulin. Arch Biochem Biophys. 379, 28-36.

Research Interests:
Most proteins are degraded by the Proteasome. However, the role of the Proteasome in cardiac physiology and pathophysiology is not well understood. We are currently investigating the proteasome using a mutli-functional proteomic approach. A critical regulator of muscle contraction is the troponin complex. Mutations in the three subunits which make up troponin (troponin T, troponin I and troponin C) are assocaited with hypertrophic, dilated and restrictive cardiomyopathies. We are currently investigating different troponin mutations in vitro and in vivo using transgenic mouse models which would allow us to target heart troponins for future treatment of cardiac diseases.

Laboratory Personnel:
Muscle Physiology and Proteomics Laboratory/176 Briggs Hall - Qian Xu, MD, PhD Susan Nguyen, BSc Rylie Siu, BSc
http://www.npb.ucdavis.edu/labs/gomes/index_files/Page649.htm

Courses Taught:
EXB 110 Exercise Metabolism - Term(s): Spring