Faculty Profile

Stephen C. Kowalczykowski
Distinguished Professor of Microbiology
Microbiology (College of Biological Sciences)
Molecular and Cellular Biology (College of Biological Sciences)
Briggs Hall 310
Office 752-5938
Lab 754-9702, 9703, 9704
sckowalczykowski@ucdavis.edu
http://www.mic.ucdavis.edu/sklab/kowalczykowskilab.htm
[Picture of Stephen C. Kowalczykowski]

Degrees:
1976 - PhD - Georgetown University - Chemistry (Biochemistry)
1972 - BS - Rensselaer Polytechnic Institute - Chemistry

Awards:
Phi Lambda Upsilon, Chemical Honor Society, 1971
Sigma Xi, 1974
American Cancer Society Postdoctoral Fellowship, 1977-1980
American Cancer Society Junior Faculty Research Award, 1983-1986
National Institutes of Health MERIT Award, 2000-2010
American Association for the Advancement of Science, Fellow, 2001
American Academy of Microbiology, Fellow, 2003
University of California, Davis, Academic Senate Faculty Research Lecture Award, 2005
American Academy of Arts & Sciences, Fellow, 2005
National Academy of Sciences, Member, 2007

Department and Center Affiliations:
Section of Microbiology
Section of Molecular and Cellular Biology

Professional Societies:
American Society for Biochemistry and Molecular Biology, FASEB
American Chemical Society, Division of Biological Chemistry
American Society for Microbiology
American Association for the Advancement of Sciences
Biophysical Society

Grad Group Affiliations and Specialties:
Biochemistry and Molecular Biology
Biophysics
Genetics
Microbiology

Publications:
Spies, M. and Kowalczykowski, S.C. (2006). The RecA-binding locus of RecBCD enzyme defines a generalized domain for recruitment of DNA strand exchange proteins. Mol. Cell, 21, 573-580.

Amitani, I., Baskin, R.J., and Kowalczykowski, S.C. (2006). Visualization of Rad54, a chromatin-remodeling protein, translocating on single DNA molecules. Mol. Cell, 23, 143-148

Galletto, R., Amitani, I., Baskin, R.J., and Kowalczykowski, S.C. (2006). Direct observation of individual RecA filaments assembling on single DNA molecules. Nature, 443, 875-878

Sugiyama, T., Kantake, N., Wu Y., and Kowalczykowski, S.C. (2006). Rad52-mediated DNA annealing after Rad51-mediated DNA strand exchange promotes second ssDNA capture. EMBO J., 25, 5539–5548

Nimonkar, A.V., Amitani, I., Baskin, R.J., and Kowalczykowski, S.C. (2007). Single-molecule imaging of Tid1/Rdh54, a Rad54 homolog that translocates on duplex DNA and can disrupt joint molecules. J. Biol. Chem., 282, 30776 - 30784

Spies, M., Amitani, I., Baskin, R.J., and Kowalczykowski, S.C. (2007). RecBCD enzyme switches lead motor subunits in response to Chi-recognition. Cell, 131, 16, 694-705

Research Interests:
Biochemical mechanism of genetic recombination. DNA helicases, DNA pairing proteins, DNA binding proteins, and nucleases; DNA intermediates involved in genetic recombination. Physical and structural aspects of protein-nucleic acid interactions. Single-molecule biophysics; nanotechnology.
http://www-mic.ucdavis.edu/sklab/kowalczykowskilab.htm

Laboratory Personnel:
Briggs Hall 303 - Bian Liu, Joe Hilario, Edgar Valencia-Morales, Ichiro Amitani
http://www.mic.ucdavis.edu/sklab/people.htm

Briggs Hall 304 - Jason Bell Lian Yang, Galina Drofyak, Valentin Taryanik
http://www.mic.ucdavis.edu/sklab/people.htm

Briggs Hall 306 - Ryan Jensen, Behzad Rad, Clarke Conant, Aura Carriera, Jason Wong
http://www.mic.ucdavis.edu/sklab/people.htm

Briggs Hall 307 - Tony Forget, Taeho Kim, Katsumi Morimatsu, Amitabh Nimonkar
http://www.mic.ucdavis.edu/sklab/people.htm

Briggs Hall 315 - Jode Planck, Petr Cejka, Paul Pease
http://www.mic.ucdavis.edu/sklab/people.htm

Teaching Interests:


Bacterial physiology and genetics. Molecular biology and biochemistry. Principles of protein-nucleic acid interactions. Advanced concepts in DNA metabolism.

Courses Taught:
MIC 298 Advanced concepts in DNA metabolism - Term(s): Spring
MIC 263 Principles of Protein-Nucleic Acid Interactions - Term(s): Spring