Faculty Profile
|
Francis J. McNally
Associate Professor of Molecular and Cellular Biology [other or N/A] 3225 Life Sciences Addition Office 754-8018 Lab fjmcnally@ucdavis.edu |
Degrees:
1990 - PhD - University of California, Berkeley - Biochemistry
1984 - BA - Princeton University - Biochemical Sciences
Department and Center Affiliations:
Section of Molecular and Cellular Biology
Grad Group Affiliations and Specialties:
Biochemistry and Molecular Biology
Cell and Developmental Biology
Publications:
Srayko, M., Buster, D.W., Bazirgan, O.A., McNally, F.J., and P.E. Mains. . 2000. MEI-1/MEI-2 katanin-like microtubule severing activity is required for C. elegans meiosis.. Genes and Development. 14:1072-1084
McNally, K.P., Bazirgan, O.A., and F.J. McNally. 2000. Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin.. J. Cell Sci.. 113:1623-1633
Buster, D.W., McNally, K., and F.J. McNally. 2002. Katanin inhibition prevents the redistribution of g-tubulin at mitosis. J. Cell Science 115: 1083-1092.
McNally, K.P., Buster, D. and F.J. McNally. 2002. Katanin-mediated microtubule severing can be regulated by multiple mechanisms. Cell Motil. Cytoskel. 53: 337-349.
Yang, H., McNally, K., and F.J. McNally. 2003. MEI-1/Katanin is Required for Translocation of the Meiosis I Spindle to the Oocyte Cortex in C. elegans. Dev. Biol. 260: 245-259..
Yang, H., Mains, P.E., and F.J. McNally. 2005. Kinesin-1 mediates translocation of the meiotic spindle to the oocyte cortex through KCA-1, a novel cargo adapter. J. Cell Biol. 169: 447-457.
McNally, K.L., and F.J. McNally. 2005. Fertilization initiates the transition from anaphase I to metaphase II during C. elegans meiosis. Dev. Biol. 282: 218-230.
McNally, K., Audhya, A., Oegema, K., McNally, F.J. 2006. Katanin controls mitotic and meiotic spindle length. J. Cell Biol. 175: 881-891.
Research Interests:
Meiosis is a process by which animals, plants and fungi reduce chromosome number four-fold to produce haploid gametes. In females of both plants and animals, only one of four sets of chromosomes segregated during meiosis is inherited by a gamete. In animals, this asymmetric inheritance is mediated by asymmetric meiotic spindle positioning and highly asymmetric cell divisions that yield a large haploid egg. We are interested in the mechanisms that mediate these asymmetric divisions and utilize C. elegans because both meiotic divisions can be filmed in utero using fluorescent protein fusions and time-lapse imaging. We use a combination of classical genetics, RNAi and biochemistry to elucidate the roles of proteins that regulate microtubule-based motility, microtubule organization and microtubule dynamics in meiotic cell division.
http://www.mcb.ucdavis.edu/faculty-labs/mcnally/
Teaching Interests:
Cell biology.
Courses Taught:
MCB 144 Mechanisms of Cell Division - Term(s): Winter
MCB 221D Cellular biochemistry - Term(s): Winter
CDB 205 Cell Biology of the Cytoskeleton - Term(s): Fall