Faculty Profile
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Robert H Weiss
Professor Internal Medicine: Division of Nephrology (School of Medicine) Chief of Nephrology, Sacramento VA Medical Center GBSF rm 6312 Office (530) 752-4010 Lab 530-752-8868 rhweiss@ucdavis.edu |
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| cyclins and cyclin inhibitors, cancer growth control, metabolomics and proteomics, polycystic kidney disease | |
Degrees:
1991 - - University of California, San Francisco - Fellowship, Nephrology
1984 - MD - University of California, Irvine - Medicine
1980 - MS - University of California, Los Angeles - Medical Physics
1978 - MS - University of California, Los Angeles - Physical Chemistry
1976 - BA - University of California, Santa Cruz - Chemistry
Department and Center Affiliations:
UC Davis Cancer Center
Grad Group Affiliations and Specialties:
Biochemistry and Molecular Biology
Cell and Developmental Biology
Molecular, Cellular, and Integrative Physiology
Non-DBS Grad Group(s) - Immunology Comparative Pathology
Publications:
Weiss RH, Joo A and CJ Randour. 2000. p21Waf1/Cip1 is an assembly factor required for PDGF-induced vascular smooth muscle cell proliferation. Journal of Biological Chemistry. 275:10285-10290
Davis BB, Thompson DA, Howard LL, Morisseau C, Hammock BD and RH Weiss. 2002. Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation. Proceedings of the National Academy of Sciences (USA). 99(4):2222-2227
Lin, P.Y., Fosmire, S.P., Baksh, S., Modiano, J.F., Weiss, R.H. Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance, Molecular Cancer, 6:16, 2007
Park, S.H., Park, J.Y., Weiss, R.H. Antisense attenuation of p21 sensitizes kidney cancer to apoptosis in response to conventional DNA-damaging chemotherapy associated with enhancement of phospho-p53, Journal of Urology 180(1):352-60, 2008
Park, S.H., Wang, X., Liu, R., Lam, K.S., Weiss, R.H. High throughput screening of a small molecule one-bead-one-compound combinatorial library to identify attenuators of p21 as chemotherapy sensitizers, Cancer Biology & Therapy, in press
Kim, K.M., Aronov, P.A., Zakharkin, S.O., Anderson, D., Perroud, B., Weiss, R.H., Urine metabolomic analysis for kidney cancer detection and biomarker discovery, Molecular and Cellular Proteomics, in press
Research Interests:
Cell signaling, with an emphasis on vascular smooth muscle cell mitogenesis. Metabolomics, Cyclins, cyclin kinases, tumor suppressor homologues, and epoxyeicosanoids in vascular and cancer cell growth.