Faculty Profile
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Stanley Meizel
Professor of Cell Biology and Human Anatomy Cell Biology and Human Anatomy (School of Medicine) 3402 Tupper Hall Office 752-7108 Lab smeizel@ucdavis.edu |
Degrees:
1966 - PhD - University of Rochester School of Medicine - Biochemistry
1959 - BS - Queens College - Chemistry
Grad Group Affiliations and Specialties:
Cell and Developmental Biology
Publications:
2000 Sato, Y., Son, J.-H, Tucker, R.P. and S.Meizel. The Zona Pellucida-Initiated Acrosome Reaction: Defect Due to Mutations in the Sperm Glycine Receptor/Cl- Channel. Dev. Biol. 227: :211-218.
2002 Bray, C., Son, J-H, Kumar, P., Harris, J. and S. Meizel. A role for the human glycine receptor/Cl- channel in the acrosome reaction initiated by recombinant ZP3. Biology of Reproduction 66: 91-97. 108. 2002 Bray, C., Son, J-H, and S. Meizel.. A nicotinic acetylcholine receptor is involved in the acrosome reaction of human sperm initiated by recombinant human ZP3. Biology of Reproduction 67:782-788.
2002 Bray, C., Son, J-H, and S. Meizel. A nicotinic acetylcholine receptor is involved in the acrosome reaction of human sperm initiated by recombinant human ZP3. Biology of Reproduction 67:782-788.
Research Interests:
In order to fertilize the egg, mammalian sperm must first undergo the acrosome reaction (AR), a fusion and vesiculation of sperm head membranes. My lab is investigating both the initiators of this exocytotic event and the molecular changes in sperm stimulated by those initiators. In vitro studies of human sperm and mouse sperm are being emphasized. Techniques used include indirect immunofluorescence, spectroflurometric assays, laser confocal microscopy and video/image analysis of ion changes, molecular biology techniques (in collaboration with another lab), affinity chromatography, and Western blot. In particular, we are attempting to identify a sperm plasma membrane progesterone receptor involved in the progesterone-initiated AR and to characterize the roles of sperm neurotransmitter receptor/ion channels (glycine receptor and nicotinic acetylcholine receptor) in the AR initiated by the egg zona pellucida.
Teaching Interests:
Gametes and fertilization. Reproductive biology. Microscopic anatomy.