Faculty Profile

Jim Trimmer
Professor
Neurobiology, Physiology, and Behavior (College of Biological Sciences)
School of Medicine: Physiology and Membrane Biology
1009 Life Sciences
Office (530) 754-6075
Lab (530) 754-6076
jtrimmer@ucdavis.edu
[Picture of Jim Trimmer]

Degrees:
1987 - PhD - UC San Diego/Scripps Inst. Oceanography - Marine Biology
1981 - BA - UC San Diego - Biology

Awards:
2000-2007 Jacob Javits Neuroscience Investigator (MERIT) Award, NINDS
1994-1999 Established Investigatorship, American Heart Association

Department and Center Affiliations:
Center for Neuroscience
Director, UC Davis/NIH NeuroMab Facility (www.neuromab.org)

Professional Societies:
Society for Neuroscience
American Society for Cell Biology
Biophysical Society

Grad Group Affiliations and Specialties:
Biochemistry and Molecular Biology
Cell and Developmental Biology
Neuroscience

Publications:
Seikel, E. and J. S. Trimmer. (2009). Convergent Modulation of Kv4.2 Channel Alpha Subunits by Structurally Distinct DPPX and KChIP Auxiliary Subunits. Biochemistry 48:5721-5730.

Mikula, S., Parrish, S. K., Trimmer, J. S., and E. G. Jones. (2009). Complete 3D Visualization of Primate Striosomes by KChIP1 Immunostaining. J. Comp. Neurol. 514: 507-517.

Vacher, H., and J. S. Trimmer. (2009). Shaker Family Kv1 Voltage-gated Potassium Channels in Mammalian Brain Neurons. (Chapter 5, pp. 127-154). In Structure, Function and Modulation of Neuronal Voltage Gated Ion Channels. (V. Gribkoff and L. K. Kaczmarek, eds.). John Wiley and Sons, Hoboken.

Mohapatra, D. P., Misonou, H, Pan, S.-J., Held, J. E., Surmeier, D. J., and J. S. Trimmer. (2009). Modulation of the Kv2.1 Potassium Channel Contributes to Activity-Dependent Regulation of Intrinsic Excitability in Hippocampal Neurons. Channels 3: 46-56.

Rasband, M. N., and J. S. Trimmer. (2008). Ion Channel Localization in Axons. (pp. 229-235). In Encyclopedia of Neuroscience. (L. R. Squire, ed.). Elsevier Academic Press, London.

Yan, J., Olsen, J. V., Park, K.-S., Li, W., Bildl, W., Schulte, U., Aldrich, R. W., Fakler, B., and J. S. Trimmer. (2008). Profiling the Phospho-status of the BKCa Channel Alpha Subunit in Rat Brain Reveals Unexpected Patterns and Complexity. Mol. Cell. Proteomics 7:2188-2198.

Martinez, H. D., Jasavala, R. J., Hinkson, I., Fitzgerald, L., Trimmer, J. S., Kung, H.-J., and M. E. Wright. (2008). RNA Editing of Androgen Receptor Gene-Transcripts in Prostate Cancer Cells. J. Biol. Chem. 283:29938-29949.

Vacher, H., Mohapatra, D. P., and J. S. Trimmer. (2008). Localization and Targeting of Voltage-Gated Ion Channels in Mammalian Central Neurons. Physiol. Rev. 88:1407-1447.

Monaghan, M. M., Menegola, M., Vacher, H., Rhodes, K. J., and J. S. Trimmer. (2008). Altered Expression and Localization of Hippocampal A-Type Potassium Channel Subunits in the Pilocarpine-Induced Model of Temporal Lobe Epilepsy. Neurosci. 156:550-562.

Menegola, M., Misonou, H., Vacher, H., and J. S. Trimmer. (2008). Dendritic A-type Potassium Channel Subunit Expression in CA1 Hippocampal Interneurons. Neurosci. 154:953-964.

Ogawa, Y., Horresh, I., Trimmer, J. S., Bredt, D. S., Peles, E., and M. N. Rasband. (2008). PSD-93 Clusters Kv1 Channels at Axon Initial Segments Independent of Caspr2. J. Neurosci. 28: 5731-5739.

Mohapatra, D. P., Siino, D. F., and J. S. Trimmer. (2008). Interdomain Cytoplasmic Interactions Govern the Intracellular Trafficking, Gating and Modulation of the Kv2.1 Channel. J. Neurosci. 28: 4982-4994.

Rhodes, K. J., and J. S. Trimmer. (2008). Antibody-based Validation of CNS Ion Channel Drug Targets. J. Gen. Physiol. 131:407-413.

Park, K.-S., Yang, J.-W., Seikel, E., and J. S. Trimmer. (2008). Potassium Channel Phosphorylation in Excitable Cells: Providing Dynamic Functional Variability to a Diverse Family of Ion Channels. Physiology 23:49-57.

Research Interests:
Cell signaling in mammalian neurons, neuronal cell biology, membrane protein trafficking and function

Laboratory Personnel:
1111 LS - Jesus Aguado, Junior Specialist; Oscar Cerda, PhD, Postdoctoral Fellow; Fabio Iannotti, Visiting PhD Student; Moon Young Kim PhD, Postdoctoral Fellow; Luci Lopez PhD, Postdoctoral Fellow; Danielle Mandikian, BMB Graduate Student; Colleen Manning, Staff Research Associate; Andrea Reynaga, Staff Research Associate; Jon Sack PhD, Postdoctoral Fellow
http://www.npb.ucdavis.edu/npbdirectory/trimmer.html

Courses Taught:
NSC 221 Cellular Neuroscience - Term(s): Fall
NPB 107 Cell Signaling in Health and Disease - Term(s): Winter