Faculty Profile
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Paul FitzGerald
Professor Cell Biology and Human Anatomy (School of Medicine) 3420 Tupper Hall Office +1 530 752 7130 Lab pgfitzgerald@ucdavis.edu |
Degrees:
1982 - PhD - UCLA Medical School - Cell Biology and Anatomy
Awards:
Bradley Staatsma Lecturer, UCLA Medical School
Department and Center Affiliations:
Dept of Cell Biology and Human Anatomy
Professional Societies:
Am Society for Cell Biology, Assoc for Research in Vision and Ophthalmology
Grad Group Affiliations and Specialties:
Biochemistry and Molecular Biology
Cell and Developmental Biology
Publications:
2008 Kyoung-he Yoon, Tom Blankenship, Bradley Shibata, and Paul FitzGerald Resisting the effects of aging: A function for the lens Beaded Filament Investigative Opthalmology and Visual Science (In Press)
2007 Madhu Budamagunta, John Hess, Paul FitzGerald and John Voss Describing the structure and assembly of protein filaments by EPR spectroscopy of spin labeled side chains. Cell Biochem and Biophys (In Press)
2007 Blankenship, T, Bradshaw, L, Shibata, B, and FitzGerald P Structural specializations emerging late in mouse lens fiber cell differentiation. Investigative Ophthalmology and Visual Science 2007 48: 3269-3276
2007 Pittenger, JT, Hess, JF, and FitzGerald, PG Identifying the role of specific motifs in the lens fiber cell-specific intermediate filament protein phakosin. Investigative Ophthalmology and Visual Science (In Press)
2006 John F. Hess, Madhu S. Budamagunta, Rebecca L Shipman, Paul G. FitzGerald, John C. Voss, Ph.D Characterization of the Linker 1-2 Region in Human Vimentin Using Site Directed Spin Labeling and Electron Paramagnetic Resonance Biochemistry 45:11737-43.
2005 Hess, John., Madhu S. Budamagunta, Paul FitzGerald, John C. Voss. Characterization of Structural Changes in Vimentin Bearing an EBS-like Mutation Using Site Directed Spin Labeling and Electron Paramagnetic Resonance Journal of Biological Chemistry 280:2141-6
2004 Hess, John., Madhu S. Budamagunta, Paul G.FitzGerald, John C. Voss. Characterization of Structural Changes in Vimentin Bearing an EBS-like Mutation Using Site Directed Spin Labeling and Electron Paramagnetic Resonance J. Biological Chemistry (In Press)
Research Interests:
We've identified two unique intermediate filament proteins, expressed only in the lens of the eye. We are exploring the function of these proteins, and the unique cytoskeletal structure they form, using a range of techniques including cell biological, molecular genetic, knockout and transgenic, and biophysical to determine 1) relationships between these filaments and other cellular structures, 2) regulation of expression 3) structure of the filaments 4) determination of structural motifs required for assembly
Laboratory Personnel:
Andrew Yokovlev, BS - Rsearch Associate
Atya Aziz, PhD - Postdoctoral Fellow
John Hess, Ph.D., Research Cell Biologist
Kyoung-hye Yoon, Graduate Student, Cell and Developmental Biology
Michael Stout - Staff Research Associate
Tom Blankenship, Ph.D., Research Cell Biologist
Teaching Interests:
Medical Microscopic Anatomy, CHA 402 Techniques in cell Biology, CDB 200 The Visual System, NSC 298 Med Microbiology and Immunology MMI 480A Med Micro and Immunology MMI 188