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Degrees: 1965 - PhD - Ohio State University - 1961 - MS - University of Wisconsin - Biochemistry 1959 - BS - University of Wisconsin - Chemistry Awards: Fulbright Scholar, Uruguay (1982 and 1999), Argentina (1999) Frank R. Blood Award, Society of Toxicology ICI/Zeneca Traveling Scholar Award, Society of Toxicology School of Medicine: Faculty Research Award and Joan Oettinger Memorial Research Award UCD Distinguished Public Service Award, 2003 Gaspar de Portola Lectureship, Barcelona, 2000 Department and Center Affiliations: Director, UCD Fogarty International Center NIEHS Center for Environmental Health Sciences, Co-Investigator Professional Societies: ASBMB Society of Toxicology Grad Group Affiliations and Specialties: Biochemistry and Molecular Biology Non-DBS Grad Group(s) - Pharmacology and Toxicology Publications: Rufo C., Hammock B.D., Gee S.J., Last J.A., Gonzalez-Sapienza G. (2004) Robust and Sensitive Monoclonal Enzyme-Linked Immunosorbent Assay for the Herbicide Molinate. Journal of Agricultural and Food Chemistry, 52:182-187. Ellahuenñe, M.F., Perez-Alzola, L.P., Farfan-Urzua, M., Gonzalez-Hormazabal, P. Garay, M., Olmedo, M.I., and Last, J.A (2004) Preliminary evaluation of DNA damage related with the smoking habit measured by the Comet assay in whole blood cells. Cancer Epidemiology, Biomarkers & Prevention, 13:1223-1229. Kenyon, N.J., Gohil, K., and Last, J.A. (2003) Susceptibility to ovalbumin-induced airway inflammation and fibrosis in iNOS-deficient mice: mechanisms and consequences. Toxicology and Applied Pharmacology, 191:2-11. Gohil, K., Cross, C.E,. and Last, J.A. (2003) Ozone induced disruptions of lung transcriptosomes. Biochemical and Biophysical Research Communications, 305:719-728. Kenyon, N.J. van der Vliet, A., Schock, B., Okamoto, T., McGrew, G.M., and Last, J.A. (2002) Susceptibility to Ozone-Induced Acute Lung Injury in iNOS-Deficient Mice. American Journal of Physiology: Lung Cell Molecular Physiology 282(3): L540-5. Kenyon, N.J., Ward, R.W., and Last, J.A. (2003) Airway fibrosis in a mouse model of airway inflammation. Toxicology and Applied Pharmacology, 186:90-100. Kenyon, N.J., Ward, R.W., McGrew, G., and Last, J.A. (2003) TGF-B1 causes airway fibrosis and increased collagen I and III mRNA in mice. Thorax, 58:772-777. Samimi, A. and Last, J.A. (2001) Mechanism of the Inhibition of Lysyl Hydroxylase by the organophosphates malathion and malaoxon. Toxicol. Appl. Pharmacol., 176:181-186. Armstrong, L.C. and Last, J.A.. (1995). Rat lysyl hydroxylase: molecular cloning, mRNA distribution, and expression in a baculovirus system. Biochimica et Biophysica Acta. 1264:93-102 Research Interests: General: regulation of protein synthesis, animal models of asthma, collagen biochemistry, lung toxicology, regulation of gene expression, environmental toxicology. Specific: collagen metabolism by asthmatic lungs, lung inflammation, mechanism of action of air pollutants Laboratory Personnel: 6413 Genomics Building - Lisa Temple, Vivek Mathrani, Nick Kenyon, Sarah Liu, Erin O'Rourke, Kishorchandra Gohil, Anne Huang http://tsrtp.ucdavis.edu Field Sites: Universidad de la Republica, Montevideo, Uruguay; University of Chile, Santiago, Chile Teaching Interests:Biochemistry, Medicine, Toxicology, California-Based Mystery Novels, Davis Honors Challenge, Freshman Seminars Courses Taught: FRS 001 California Mystery Novels - Term(s): Winter HNR 094 Davis Honors Challenge - Term(s): Spring PTX 290 Grant Writing and Preparation for the Qualifying Examination - Term(s): Fall MDS 400 Medical Problem Solving - Term(s): Winter,Spring Personal Interests: South America, Wine, Dogs http://ucdfogartyprogram.ucdavis.edu |