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Degrees: 1990 - PhD - University of Wisconsin-Madison - Plant Pathology 1982 - BS - Santa Clara University - Biology Awards: Human Frontier Science Program Organization Fellow Life Sciences Research Foundation Postdoctoral Fellow Professor, International Graduate School in Bioinformatics and Genome Research, Universitat Bielefeld, Germany Samuel Roberts Noble Foundation Non-Resident Fellow, 2007-2012 Fulbright Scholar 2006, National University of Cuyo, Argentina Department and Center Affiliations: Department of Plant Pathology Faculty Director, College of Agricultural and Environmental Sciences Genomics Facility Professional Societies: American Society for Plant Biology American Phytopathological Society Grad Group Affiliations and Specialties: Genetics Plant Biology Non-DBS Grad Group(s) - Plant Pathology, Viticulture and Enology Publications: Selected Publications Middleton, P., Jakab, J., Penmetsa, R.V., Starker, C., Doll, J., Kalo, P., Prabu, R., Marsh, J., Mitra, R., Kereszt, A., Dudas, B., VandenBosch, K., Long, S., Cook, D., Kiss, G., and Oldroyd, G. (2007) An ERF transcription factor in Medicago truncatula that is essential for Nod factor signal transduction. The Plant Cell 19:1-14. Messinese, E., Mun, J.H., Yeun, L.H., Jayaraman, D., Lougnon, G., Rougé, P., Barre, A., Bono, J.J., Cook, D.R., and Ané, J.M. (2007) A novel nuclear protein interacting with the symbiotic DMI3 CCaMK. MPMI 20:912-21. Riely, B.K., Lougnon, G., Ane, J.-M., Cook, D.R. (2007) The symbiotic ion channel homolog DMI1 functions in the nuclear membrane of Medicago truncatula roots. The Plant Journal 49:208-216. Javot, H., Penmetsa, R.V., Terzaghi, N., Cook, D.R., and Harrison, M.J. (2007) Phosphate delivery by MtPT4 is indispensable for the arbuscular mycorrhizal symbiosis. Proc. Natl. Acad. Sci. USA Proc. Natl. Acad. Sci. USA 104:1720-1725. Cannon, SB, Sterck, L, Rombauts, S, Sato, S, Wang, X, Mudge, J, Vasdewani, J, Cheung, F, Gouzy, JP, Schiex, T, Spanngl, M, Schoof, H, Nicholson, C, Humphays, S, Mayer, K, Rogers, J, Quetier, F, Oldroyd, GE, Debelle, F, Cook, DR, Town, CD, Roe, BA, Tabata, S, Van de Peer, Y, Young, ND (2006) Legume genome evolution viewed through the Medicago truncatula and Lotus japonicus genomes. Proc. Natl. Acad. Sci. USA Proc. Natl. Acad. Sci. USA 103:14959-14964. Choi, H.K., Luckow, M.A., Doyle, J., and Cook, D.R. (2006) Development of nuclear gene-derived molecular markers linked to legume genetic maps. Molecular Genetics and Genomics. 276:56-70. Debolt, S, Cook, DR, and Ford, CM (2006) L-Tartaric acid synthesis from vitamin C in higher plants. Proc. Natl. Acad. Sci. USA 103:5608-5613. Mun, JH, Kim, DJ, Choi, HK, Gish, J, Debelle, F, Mudge, J., Denny, R., Endre, G, Denarie, J, Kiss, GB, Roe, B, Young, ND, and Cook , DR (2006) Distribution of microsatellites in the genome of Medicago truncatula: A resource of genetic markers that integrate genetic and physical maps. Genetics 172: 2541-2555. Goes da Silva, F., Iandolino, A., Al-Kayal, F., Bohlmann, M.C., Cushman, M.A., Lim, H., Figueroa, R., Leslie, A., Xu, J., Kabuloglu, E.K., Tattersall, E., Ergul, A., Baek, J.M., Cramer, G.R., Cushman, J.C., Cook, D.R. (2005) Characterizing the grape transcriptome. Analysis of expressed sequence tags from multiple Vitis species and development of a compendium of expression during berry development. Plant Physiology 139: 574-597. Ane, J.M., Kiss, G.B., Riely, B.K., Penmetsa, R.V., Ayax, C., Levy, J., Debelle, F., Baek, J.M., Kalo, P., Roseberg, C., Roe, B.A., Long, S.R., Denarie, J., and Cook, D.R. (2004). Medicago truncatula DMI1 required for bacterial and fungal symbioses in legumes. Science 303:1364-1367. Riely, B., Ane, J-M., Penmetsa, R.V., and Cook, D.R. (2004) Genetic and genomic analysis in model legume systems bring Nod factor signaling to center stage. Current Opinion in Plant Biology 7:408-413. Choi, H.-K., Mun, J.-H., Kim, D.-J., Zhu, H., Baek, J.-M., Mudge, J., Roe, B., Ellis, T.H.N., Doyle, J., Kiss, G.B., Young, N.D., and Cook, D.R. (2004) Estimating genome conservation between crop and model legume species. Proc. Natl. Acad. Sci. USA 101:15289-15294. Penmetsa, R.V., Frugoli, J.A., Smith, L., Long, S.R., and Cook, D.R. (2003). Dual Genetic Pathways Controlling Nodule Number In Medicago truncatula. Plant Physiology 131:998-1008. Zhu, H.Y., Cannon, S., Young, N.D., and Cook, D.R. (2002). Phylogeny and Genomic Organization of the TIR and non-TIR NBS-LRR Resistance Gene Family in Medicago truncatula, MPMI 15:529-539. Wais, R.J., Galera, C., Catoira, R., Penmetsa, R.V., Cook, D., Gough, C., Dénarié, J., and Long, S.R. (2000). Early symbiosis mutants of Medicago truncatula show a block in Ca++ spiking. Proc. Natl. Acad. Sci. USA, 97: 13407-13412. Catoira, R., Galera C., de Billy F., Journet E.P., Maillet F., Penmetsa, V., Rosenberg C., Gough, C., Cook D., and Denarie J. (2000). Identification of four genes of Medicago truncatula controlling steps in Nod factor transduction. Plant Cell 12, 1647-1665. Cook, D. (1999). Medicago truncatula - a model in the making! Current Opinion in Plant Biology, 2 (4) 301-304. Penmetsa, R.V. and Cook, D. (1997). A legume ethylene-insensitive mutant hyperinfected by its rhizobial symbiont. Science 275, 527-530 Research Interests: Area of Specialization: Plant genomics and bioinformatics, genetics, molecular and cellular biology. Research Statement: The Cook laboratory is involved in two broad endeavors. We are using the annual legume, Medicago truncatula, as a model for genome structure throughout the Papilionoid legumes. Projects in this area include determining the genomic architecture of resistance gene homologs and examining conserved genome structure and function across 60 MYA of Papilionoid evolution. As part of an international consortium, we are translating knowledge of genome structure into tools for molecular breeding and diversity analysis in legume crops. This part of the program has a decidedly international focus, with on-going activities in India and Africa. In a second area of emphasis, my research group is involved in the genetic and molecular characterization of plant genes that regulate associations with symbiotic and pathogenic microorganisms. Projects include genetics, biochemistry and cell biology of signal transduction, and genetic and molecular analysis of symbiont-induced plant development. We are particularly focused on characterizing components of the signaling pathway that are not accessible by traditional forward genetics and in understanding the cross talk between external and internal hormonal cues during symbiotic development. The laboratory is currently funded by the National Science Foundation Plant Genome Program, by the Department of Energy's Energy Biosciences Program, and by the Bill and Melinda Gates Foundation through the Generation Challenge Program. Medicago web site http://www.medicago.org Cook lab web site http://medicago.ucdavis.edu Grape web site http://www.vitaceae.org Laboratory Personnel: Please follow the "people" link on the Cook lab web site. http://medicago.ucdavis.edu Teaching Interests:SAS20: Genetics and Society 1. To provide non-science majors with the basic concepts of genetic and modern methods of biotechnology, 2. To educate students in the process of scientific discovery and the public perception of the process. 3. Empower students to evaluate for themselves the present and future impact of genetics on society. PBI 200C: Plant-microbe interactions, with a focus on the nature of signal exchange between plants and their microbial associates. Lectures include an overview of our current understanding of symbiotic and pathogenic interactions, including recent literature. Courses Taught: PBI 200C Plant Biology Core Course - Term(s): Spring SAS 020 Genetics and Socitey - Term(s): Fall HON 090 Honors Genetics and Society - Term(s): Fall |
![[Picture of Douglas Cook]](/FacultyProfiles/Common/PersonalImages/1745.jpg)