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Degrees: 1995 - PhD - University of Paris - France - DNA recombination in Bacteria 1991 - MS - University of Paris - France - DNA repair and recombination Awards: Excellence in Research PhD award - INRA, 1991-1995 NATO post doctoral fellowship - 1996-1998 Basil O'Connor Starter Research Scholar Award - March of dimes foundation - 2005-2007 Department and Center Affiliations: Department of Molecular and Cellular Biology Professional Societies: DNA Methylation Society Grad Group Affiliations and Specialties: Biochemistry and Molecular Biology Cell and Developmental Biology Genetics Publications: Kareta M. S., Botello Z., Ennis J. E., Chou C. and Chedin F. (2006) Reconstitution and mechanism of the stimulation of de novo methylation by human DNMT3L. Journal of Biological Chemistry. 281:25893-25902. Chen Z., Mann J.R., Hsieh C.L., Riggs A.D. and Chedin F. (2005). Physical and functional interactions between the human DNMT3L protein and members of the de novo methyltransferase family. Journal of Cellular Biochemistry. 95: 902-917 Yu K., Chedin F., Hsieh C.L., Wilson T.E. and M.R. Lieber. (2003). R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nature Immunology. 4: 442-451. Chedin F., Lieber M.R. and C.L. Hsieh. (2002) The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a. Proceedings of the National Academy of Sciences USA. 99: 16916-16921. Research Interests: Molecular mechanisms of epigenetic gene regulation. Mammalian DNA methyltransferases catalyze the addition of methyl groups to the carbon 5 of the cytosine ring located within CG dinucleotides. DNA methylation, particularly when applied to CG-rich promoter sequences, has been shown to silence gene expression in a heritable manner. The transcriptional silencing associated with 5-methylcytosine is required for fundamental physiological processes such as embryonic development, protection against intragenomic parasites, X-inactivation and genomic imprinting. In addition, aberrant promoter methylation and inappropriate silencing of tumor suppressor genes has recently emerged as a major cause leading to cancer. We are using a combination of approaches (biochemistry, structural biology, mammalian cell culture) to study the function of DNA methyltransferases in mammalian cells. Laboratory Personnel: Chedin Lab - 341 Briggs Hall - Mike Kareta, BMB graduate student / Bethany Wienholz, Genetics graduate student / Amir Moarefi, CDB graduate student / Catherine Gordon, Genetics graduate student / Duncan Johnston, Technician / Undergrads: Alex Arzeno, Yoong Wearm Lim, Madeline Nguyen, Nicole Sadler http://www.mcb.ucdavis.edu/faculty-labs/chedin/index.htm Courses Taught: MCB 162 Human Genetics - Term(s): Fall BMB 290 Mammalian Epigenetics - Term(s): Spring BMB 220L Laboratory rotation for BMB / CDB - Term(s): Fall,Winter |
![[Picture of Frederic Chedin]](/FacultyProfiles/Common/PersonalImages/1866.jpg)