Faculty Profile

Yu-Fung Lin
Assistant Professor
Anesthesiology (School of Medicine)
Physiology and Membrane Biology
TUPPER HALL, Rm. 4144
Office (530) 754-4876
Lab (530) 754-5570
yflin@ucdavis.edu
http://physiology.ucdavis.edu/lin/index.html
[Picture of Yu-Fung Lin]
Cellular and molecular physiology of ion channels: structure-function relationship and modulation

Degrees:
1995 - PhD - University of Michigan, Ann Arbor, Michigan - Physiology
1986 - MS - National Taiwan University, Taipei, Taiwan - Zoology
1984 - BS - National Taiwan University, Taipei, Taiwan - Zoology

Awards:
Duncan McCarthy Award, Michigan Chapter Society for Neuroscience, 1994
Lothman Fellowship, The Epilepsy Foundation of America, 1996-1997
Health System Research Award, UC Davis 2005-2007
Harrison Endowed Chair in Diabetes Research Award, UC Davis 2006
American Heart Association Scientist Development Grant (National Center) 2007-2010
Research Insurance Grant, UC Davis 2007-2008

Department and Center Affiliations:
Anesthesiology
Physiology and Membrane Biology

Professional Societies:
Society for Neuroscience
American Physiological Society
American Association for the Advancement of Science
Biophysical Society

Grad Group Affiliations and Specialties:
Biochemistry and Molecular Biology
Molecular, Cellular, and Integrative Physiology

Publications:
1987 Lin, A.M.Y., Pan, C.M., Lin, Y.F., Kuo, J.S. and Chai, C.Y. A cardioinhibitory area in the midbrain central tegmental field of cats. Brain Res. Bull. 18: 699-707.

1988 Chai, C.Y., Lin, Y.F., Lin, A.M.Y., Pan, C.M., Lee, E.H. and Kuo, J.S. Existence of a powerful inhibitory mechanism in the medial region of caudal medulla--with special reference to the paramedian reticular nucleus. Brain Res. Bull. 20: 51-28.

1990 Chai, C.Y., Lin, Y.F., Wang, H.Y., Wu, W.C., Yen, C.T., Kuo, J.S. and Wayner, M.J. Inhibition of spinal reflexes by paramedian reticular nucleus. Brain Res. Bull. 25: 581-588.

1991 Yen, C.T., Hwang, J.C., Su, C.K., Lin, Y.F., Yang, J.M. and Chai, C.Y. Differential actions of the median region of caudal medulla on autonomic nerve activities. Clin. Exp. Pharmacol. Physiol. 18: 743-751.

1992 Chai, C.Y., Wu, W.C., Wang, S., Su, C.K., Lin, Y.F., Yen, C.T., Kuo, J.S. and Wayner, M.J. Coexistence of autonomic and somatic mechanisms in the pressor areas of medulla in cats. Brain Res. Bull. 29: 15-26.

1994 Lin, Y.F., Browning, M.D., Dudek, E.M. and Macdonald, R.L. Protein kinase C enhances bovine alpha1beta1gamma2L GABA(A) receptor whole-cell currents expressed in L929 fibroblasts. Neuron 13: 1421-1431.

1996 Lin, Y.F., Angelotti, T.P., Dudek, E.M., Browning, M.D. and Macdonald, R.L. Protein kinase C phosphorylation of the beta1 and gamma2L subunits of the GABA(A) receptor enhances whole-cell currents expressed in L929 fibroblasts. Mol. Pharmacol. 50: 185-195.

2000 Lin, Y.F., Jan, Y.N. and Jan, L.Y. Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cell. EMBO J. 19: 942-955.

2000 Minor, D.L., Lin, Y.F., Mobley, B.C., Avelar, A., Jan, Y.N., Jan, L.Y. and Berger, J.M. The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel. Cell 102: 657-670.

2001 Ma, D., Zerangue, N., Lin. Y.F., Collins, A., Yu, M., Jan, Y.N. and Jan, L.Y. Role of ER export signals in controlling surface potassium channel numbers. Science 291: 316-319.

2001 Yi, B.A., Lin, Y.F., Jan, Y.N. and Jan, L.Y. Yeast screen for constitutively active mutant G protein-activated potassium channels. Neuron 29: 657-667.

2001 Yi, B.A., Minor, D.L., Lin, Y.F., Jan, Y.N. and Jan, L.Y. Controlling potassium channel activities: interplay between the membrane and intracellular factors. Proc. Natl. Acad. Sci. USA 98: 11016-11023.

2004 Bichet, D., Lin, Y.F., Ibarra, C.A., Huang, C.S., Yi, B.A., Jan, Y.N. and Jan, L.Y. Evolving potassium channels via yeast selection reveals structural elements important for selectivity. Proc. Natl. Acad. Sci. USA 101: 4441-4446.

2004 Lin, Y.F., Raab-Graham, K., Jan, Y.N. and Jan, L.Y. Nitric oxide stimulation of ATP-sensitive potassium channels: Involvement of Ras/MAPK kinase pathway and contribution to neuroprotection. Proc. Natl. Acad. Sci. USA 101: 7799-7804.

2007 Mao, X., Chai, Y. and Lin, Y.F. Dual regulation of ATP-sensitive potassium channels by caffeine. Am. J. Physiol. Cell Physiol. 292: C2239-C2258. Epub 2007 Feb 15

2007 Misaki, N., Mao, X., Lin, Y.F., Suga, S., Li, G.H., Liu, Q., Chang, Y., Wang, H, Wakui, M. and Wu, J. Iptakalim, a vascular KATP channel opener, closes rat pancreatic beta-cell KATP channels and increases insulin release. J. Pharmacol. Exp. Ther. 322: 871-878. Epub 2007 May 23

2008 Lin, Y.F. and Chai, Y. Modulation of the ATP-sensitive potassium channel by extracellular signal-regulated kinase-mediated phosphorylation. Neuroscience 152: 371-380. Epub 2008 Jan 9

2008 Chai, Y. and Lin, Y.F. Dual regulation of the ATP-sensitive potassium channel by activation of cyclic GMP-dependent protein kinase. Pflügers Archiv-European J. Physiol. 456: 897-915. Epub 2008 Jan 30

2009 Chen, T.Y., Lin, Y.F. and Zheng, J. Electrophysiological measurements of membrane proteins, T. Jue, (ed), Handbook on Biophysics, Vol. 1, Humana press, Totowa, NJ. (in press)

Research Interests:
Functional modulation of ion channels by post-translational mechanisms such as protein phosphorylation, dephosphorylation, lipid modification and nitrosylation; Molecular mechanisms responsible for ion channel modulation; Signaling pathway of nitric oxide-mediated modulation of KATP channel; Role of KATP channels in neuronal ischemia preconditioning; Function of GABAA receptor-ion channel complexes in experimental models of epilepsy

Laboratory Personnel:
4210/4212 Tupper Hall - Xia Mao (PGR) Yong-ping Chai (graduate student)

Teaching Interests:


Molecular and cellular physiology; Neurophysiology; Cardiovascular physiology; Ion channel physiology

Courses Taught:
MCP 210A Molecular and Cellular Physiology - Term(s): Fall
HPH 400 Medical Physiology - Term(s): Fall
PTX 202 Principles of Pharmacology and Toxicology: Cellular and Molecullar Basis of Drug Action - Term(s): Winter