Neuroscience Graduate Program

Graduate Program Faculty: Profile

David Pleasure PROFESSOR-MEDCOMP-A Neurology (School of Medicine) Director, Institute for Pediatric Regenerative Medicine Room 602A, Shriners Hospital Office 916-453-2331 Lab 916-453-2290 david.pleasure@ucdmc.ucdavis.edu
My laboratory uses cell and molecular biological techniques to study the development and regeneration of the nervous system. Our current focus is on mechanisms of death and regeneration of oligodendroglia, the myelin-forming cells of the central nervous system, that take place during experimental autoimmune encephalomyelitis.

Degrees:
63 - MD - P&S, Columbia - Medicine
59 - BA - Yale - History

Awards:
Phi Beta Kappa Yale, Alpha Omega Alpha P&S Columbia, NIH RO1 NS025044 funded through 6/2012 (year 27)
Jacob Javits Neuroscience Award, NINDS, NIH 1992-1999
Listed in "Best Doctors in America" 1993-2009
Fellow, American Association for the Advancement of Science, 2005

Department and Center Affiliations:
Professor, Neurology and Pediatrics, UC Davis School of Medicine
Director, Research, Shriners Hospitals for Children Northern California
Director, UC Davis/Shriners Institute for Pediatric Regenerative Medicine (IPRM)

Professional Societies:
Fellow, American Academy of Neurology
American Neurological Association
Society for Neuroscience

Grad Group Affiliations and Specialties:
Neuroscience
Non-DBS Grad Group(s) - Comparative Pathology

Research Interests:
Genetic and epigenetic regulation of neural stem cell lineages

Pathogenesis of diseases affecting myelin-forming cells

Laboratory Personnel:
Institute for Pediatric Regenerative Medicine - 6th floor Shriners Hospital - Currently, 2 predoctoral fellows, 2 postdoctoral fellows, and 2 research technicians

Teaching Interests:

Clinical adult and pediatric neurology

Mechanisms of glial diseases

Neurochemistry

Publications:
Bannerman P, Hahn A, Ramirez S, Morley M, Bonnemann C, Yu S, Zhang G-X, Rostami A, Pleasure D (2005) Motor neuron pathology in experimental autoimmune encephalomyelitis: studies in THY1-YFP transgenic mice. Brain 128:1877-1886.

Bannerman P, Hahn A, Gallo V, Pleasure D (2007) Astrogliosis in EAE: derivation from radial glia, and relationships to oligodendroglia. Glia 55:57-64.

Feldman DH, Horiuchi M, Keachie K, McCauley E, Bannerman P, Itoh A, Itoh T, Pleasure D (2008) Characterization of acid-sensing ion channel expression in oligodendrocyte-lineage cells. Glia 56:1238-1249.

Guo F, Ma J, McCauley E, Bannerman P, Pleasure D (2009) Early postnatal proteolipid promoter-expressing progenitors produce multilineage cells in vivo. J Neurosci 29:7256-7270.